Environmental chemical stressors as epigenome modifiers: a new horizon in assessment of toxicological effects

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	Environmental chemical stressors as epigenome modifiers: a new horizon in assessment of toxicological effects
	Shen, Heqing ; Martin, F. L. ; Su, Yanhua ; Su YH(苏艳华)
刊名	http://dx.doi.org/10.1007/s11434-013-0007-6
	2014
关键词	EPIGENETIC TRANSGENERATIONAL ACTIONS MATERNAL METHYL SUPPLEMENTS GENOMIC DNA METHYLATION HISTONE ACETYLATION CIGARETTE-SMOKE GENE-EXPRESSION LUNG-CANCER PROMOTER HYPERMETHYLATION ENDOCRINE DISRUPTORS ABERRANT METHYLATION
英文摘要	Hundred Talent Program of Chinese Academy of Sciences; Xiamen Science and Technology Fund [3502Z20122003]; National Natural Science Foundation of China [21177123]; In eukaryotic cells, chromatin transformation from euchromatin into heterochromatin as a means of controlling gene expression and replication has been known as the "accessibility hypothesis". The interplay of epigenetic changes including histone modifications, DNA methylation, RNA interference (RNAi) and other functional epigenetic components are intricate. It is believed that these changes are well-programmed, inherited and can be modified by environmental contaminant stressors. Environmentally-driven epigenetic alterations during development, e.g. embryonic, foetal or neonatal stage, may influence disease susceptibility in adulthood. Therefore, understanding how epigenome modifications develop in response to environmental chemicals and, how epigenetic-xenobiotic interactions influence human health will shed new insights into gene-environment interactions in the epidemiology of several diseases including cancer. In this review, we consider studies of chemical modifiers including nutritional and xenobiotic effects on epigenetic components in vitro or in vivo. By examining the most-studied epigenome modifications and how their respective roles are interlinked, we highlight the central role of xenbiotic-modified epigenetic mechanisms. A major requirement will be to study and understand effects following environmentally-relevant exposures. We suggest that the study of epigenetic toxicology will open up new opportunities to devise strategies for the prevention or treatment of at-risk populations.
语种	英语
出版者	SCIENCE PRESS
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93679]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Shen, Heqing,Martin, F. L.,Su, Yanhua,et al. Environmental chemical stressors as epigenome modifiers: a new horizon in assessment of toxicological effects[J]. http://dx.doi.org/10.1007/s11434-013-0007-6,2014.
APA	Shen, Heqing,Martin, F. L.,Su, Yanhua,&苏艳华.(2014).Environmental chemical stressors as epigenome modifiers: a new horizon in assessment of toxicological effects.http://dx.doi.org/10.1007/s11434-013-0007-6.
MLA	Shen, Heqing,et al."Environmental chemical stressors as epigenome modifiers: a new horizon in assessment of toxicological effects".http://dx.doi.org/10.1007/s11434-013-0007-6 (2014).