Interaction of benzo[a]pyrene with other risk factors in hepatocellular carcinoma: a case-control study in Xiamen, China

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	Interaction of benzo[a]pyrene with other risk factors in hepatocellular carcinoma: a case-control study in Xiamen, China
	Su, Yanhua ; Zhao, Benhua ; Guo, Fei ; Bin, Zhao ; Yang, Yue ; Liu, Sheng ; Han, Yaofeng ; Niu, Jianjun ; Ke, Xiayi ; Wang, Ning ; Geng, Xuesi ; Jin, Changnan ; Dai, Yichen ; Lin, Yuanyuan ; Su YH(苏艳华) ; Zhao BH(赵本华) ; Han YF(韩耀风) ; Ke XY(柯遐义) ; Dai YC(戴益琛)
刊名	http://dx.doi.org/10.1016/j.annepidem.2013.10.019
	2014
关键词	HEPATITIS-B-VIRUS HYDROCARBON-DNA ADDUCTS WHITE BLOOD-CELLS REPUBLIC-OF-CHINA CANCER-RISK AFLATOXIN EXPOSURE CIGARETTE-SMOKING ALCOHOL-DRINKING BREAST-CANCER LIVER-CANCER
英文摘要	Xiamen Municipal Science and Technology Program [3502Z20073015]; Purpose: Large epidemiologic studies about the relationship between benzo[a]pyrene (B[a]P) and hepatocellular carcinoma (HCC) have been limited. B[a]P diol epoxide (BPDE) is a highly reactive metabolite of B[a]P that binds covalently to form DNA adducts. We evaluated the interaction between B[a]P exposure with other risk factors in HCC, in a case-control study of 345 HCC and 961 healthy controls. Methods: Concentration of BPDE-DNA adducts in blood was determined by enzyme-linked immunosorbent assay. The interaction between BPDE-DNA adducts and other risk factors on HCC were evaluated by multivariate logistic regression analysis. Results: Mean concentration of BPDE-DNA adducts in blood of cases was significantly higher than that of the controls. The risk of HCC increased with elevated concentration of BPDE-DNA adducts (x(2) = 203.57, P-trend < .001) and the odds ratio was 7.44 (95% confidence interval, 5.29-10.45) for the first versus fourth quartile of adduct levels. The relative excess risk due to interaction between BPDE-DNA adducts and hepatitis B virus surface antigen and drinking was 34.71 and 54.92, and the attributable proportion due to interaction was 41.53% and 75.59%, respectively. Conclusions: The high level of BPDE-DNA adducts in blood is associated with HCC and that environmental exposure to B[a]P may increase the risk of HCC, especially among drinkers and populations with hepatitis B virus infection. (C) 2014 Elsevier Inc. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE INC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93677]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Su, Yanhua,Zhao, Benhua,Guo, Fei,et al. Interaction of benzo[a]pyrene with other risk factors in hepatocellular carcinoma: a case-control study in Xiamen, China[J]. http://dx.doi.org/10.1016/j.annepidem.2013.10.019,2014.
APA	Su, Yanhua.,Zhao, Benhua.,Guo, Fei.,Bin, Zhao.,Yang, Yue.,...&戴益琛.(2014).Interaction of benzo[a]pyrene with other risk factors in hepatocellular carcinoma: a case-control study in Xiamen, China.http://dx.doi.org/10.1016/j.annepidem.2013.10.019.
MLA	Su, Yanhua,et al."Interaction of benzo[a]pyrene with other risk factors in hepatocellular carcinoma: a case-control study in Xiamen, China".http://dx.doi.org/10.1016/j.annepidem.2013.10.019 (2014).