Prognostic Value of Ki-67 in Breast Cancer Patients with Positive Axillary Lymph Nodes: A Retrospective Cohort Study

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	Prognostic Value of Ki-67 in Breast Cancer Patients with Positive Axillary Lymph Nodes: A Retrospective Cohort Study
	Li, Feng-yan ; Wu, San-gang ; Zhou, Juan ; Sun, Jia-yuan ; Lin, Qin ; Lin, Huan-xin ; Guan, Xun-xing ; He, Zhen-yu ; Lin Q(林勤)
刊名	http://dx.doi.org/10.1371/journal.pone.0087264
	2014-02-03
关键词	INTERNATIONAL EXPERT CONSENSUS PRIMARY THERAPY ST-GALLEN PROLIFERATIVE ACTIVITY SUBTYPES MARKER HIGHLIGHTS SURVIVAL KI67 CHEMOTHERAPY
英文摘要	Sci-Tech Office of Guangdong Province [2008B060600019]; Youth Foundation of the First Affiliated Hospital of Xiamen University [XYY2012005]; education scientific research project of young teachers in Fujian Province [JB13131]; Introduction: Ki-67 expression is a biomarker for proliferation. Its prognostic value is recognized in breast cancer (BC) patients with negative axillary nodes, but is less clear in BC patients with positive axillary lymph nodes. Methods: We retrospectively reviewed the medical records of 1131 Chinese BC patients treated from January 2002 to June 2007 and 450 patients met the inclusion criteria: positive nodes, adjuvant therapy, and complete biomarker profile (estrogen receptor (ER), progesterone receptor (PR), HER2, p53, Ki-67). Univariate and multivariate regression analysis were used to correlate biomarkers and tumor characteristics with metastasis free survival (MFS) and overall survival (OS). Results: Median follow-up time was 46 months (range 5-76 months). The Ki-67 expression was associated significantly with histological grade, ER, PR, HER2, and P53 status (P < 0.05). Tumor stage, nodal stage, and ER status were independent prognostic factors for MFS. Ki-67 status was associated significantly with OS but not MFS. To determine whether the extent of LN involvement in the BC patients influenced the role of Ki-67 in survival rates, we compared these variables in patients with 1-3 positive lymph nodes (N1) to those of patients with >= 4 positive lymph nodes. Ki-67 status was an independent prognostic factor for MFS (Hazard Ratio, 3.27, P = 0.026) and overall survival (HR, 10.64, P = 0.007) in patients with 1-3 positive nodes (N1). Conclusions: The possibility that Ki-67 expression together with clinical factors can improve prediction of the prognosis of BC patients with 1 similar to 3 positive axillary lymph nodes warrants further studies.
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93670]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Li, Feng-yan,Wu, San-gang,Zhou, Juan,et al. Prognostic Value of Ki-67 in Breast Cancer Patients with Positive Axillary Lymph Nodes: A Retrospective Cohort Study[J]. http://dx.doi.org/10.1371/journal.pone.0087264,2014.
APA	Li, Feng-yan.,Wu, San-gang.,Zhou, Juan.,Sun, Jia-yuan.,Lin, Qin.,...&林勤.(2014).Prognostic Value of Ki-67 in Breast Cancer Patients with Positive Axillary Lymph Nodes: A Retrospective Cohort Study.http://dx.doi.org/10.1371/journal.pone.0087264.
MLA	Li, Feng-yan,et al."Prognostic Value of Ki-67 in Breast Cancer Patients with Positive Axillary Lymph Nodes: A Retrospective Cohort Study".http://dx.doi.org/10.1371/journal.pone.0087264 (2014).