M1 muscarinic acetylcholine receptor in Alzheimer's disease

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	M1 muscarinic acetylcholine receptor in Alzheimer's disease
	Jiang, Shangtong ; Li, Yanfang ; Zhang, Cuilin ; Zhao, Yingjun ; Bu, Guojun ; Xu, Huaxi ; Zhang, Yun-Wu ; Li YF(李艳芳) ; Bu GJ(卜国军) ; Xu HX(许华曦) ; Zhang YW(张云武)
刊名	http://dx.doi.org/10.1007/s12264-013-1406-z
	2014
关键词	AMYLOID PRECURSOR PROTEIN AFFINITY AGONIST BINDING KNOCKOUT MICE CEREBRAL-CORTEX MUTANT MICE KINASE-C IN-VIVO CHOLINERGIC MODULATION XANOMELINE IMPROVES TAU PHOSPHORYLATION
英文摘要	National Institutes of Health, USA [R01AG038710, R01AG021173, R01AG044420, R01NS046673]; Alzheimer's Association; National Natural Science Foundation of China [91332112, 81225008, 81161120496]; Fundamental Research Funds for the Central Universities of China; Fok Ying Tung Education Foundation; The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment.
语种	英语
出版者	SPRINGER
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93641]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Jiang, Shangtong,Li, Yanfang,Zhang, Cuilin,et al. M1 muscarinic acetylcholine receptor in Alzheimer's disease[J]. http://dx.doi.org/10.1007/s12264-013-1406-z,2014.
APA	Jiang, Shangtong.,Li, Yanfang.,Zhang, Cuilin.,Zhao, Yingjun.,Bu, Guojun.,...&张云武.(2014).M1 muscarinic acetylcholine receptor in Alzheimer's disease.http://dx.doi.org/10.1007/s12264-013-1406-z.
MLA	Jiang, Shangtong,et al."M1 muscarinic acetylcholine receptor in Alzheimer's disease".http://dx.doi.org/10.1007/s12264-013-1406-z (2014).