Synthesis and Anti-Breast Cancer Evaluation of Novel N-(Guanidinyl)benzenesulfonamides

CORC > 厦门大学 > 医学院－已发表论文

	Synthesis and Anti-Breast Cancer Evaluation of Novel N-(Guanidinyl)benzenesulfonamides
	Wu, Jin ; Zhong, Daixing ; Fu, Xijin ; Liu, Qingjun ; Kang, Liangqi ; Ding, Zhenqi ; Wu J(吴进) ; Kang LQ(康两期) ; Ding ZQ(丁真奇)
刊名	http://dx.doi.org/10.3390/ijms15045570
	2014
关键词	EAG K+ CHANNELS GO POTASSIUM CHANNEL OSTEOSARCOMA CELLS PROGNOSTIC-FACTORS EWINGS-SARCOMA ETHER EXPRESSION TUMORS BONE DIFFERENTIATION
英文摘要	Scientific and Technologial Innovation Programs of the Nanjing military region, China [10MA077]; A series of 4-(substituted)-N-(guanidinyl)benzenesulfonamides bearing biologically active pyrazole, pyrimidine and pyridine moieties were prepared and evaluated for their anticancer activity against human tumor breast cell line (MCF7). These sulfonamides showed promising activity with IC50 values ranging from 49.5 to 70.2 mu M. The structure-activity relationship of the synthesized compounds was studied. Interestingly, it was found that the most potent compounds in this study were the corresponding 2-cyanoacrylate 3, 3-oxobutanoate 4, pyrazole 6, pyridine 9 and pyrazole 13. Compounds 7 and 8 are nearly as active as Doxorubicin as reference drug with (IC50 values = 70.2, 68.1 mu M), while compounds 5, 10 and 11 exhibited a moderate activity.
语种	英语
出版者	MDPI AG
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93634]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wu, Jin,Zhong, Daixing,Fu, Xijin,et al. Synthesis and Anti-Breast Cancer Evaluation of Novel N-(Guanidinyl)benzenesulfonamides[J]. http://dx.doi.org/10.3390/ijms15045570,2014.
APA	Wu, Jin.,Zhong, Daixing.,Fu, Xijin.,Liu, Qingjun.,Kang, Liangqi.,...&丁真奇.(2014).Synthesis and Anti-Breast Cancer Evaluation of Novel N-(Guanidinyl)benzenesulfonamides.http://dx.doi.org/10.3390/ijms15045570.
MLA	Wu, Jin,et al."Synthesis and Anti-Breast Cancer Evaluation of Novel N-(Guanidinyl)benzenesulfonamides".http://dx.doi.org/10.3390/ijms15045570 (2014).