The Suppressive Role of SOX7 in Hepatocarcinogenesis

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	The Suppressive Role of SOX7 in Hepatocarcinogenesis
	Wang, Chong ; Guo, Yu ; Wang, Jing ; Min, Zhiqun ; Wang C(王翀)
刊名	http://dx.doi.org/10.1371/journal.pone.0097433
	2014-05-09
关键词	BETA-CATENIN GENE HEPATOCELLULAR-CARCINOMA TUMOR-SUPPRESSOR CANCER EXPRESSION PROGRESSION
英文摘要	National Natural Science Foundation of China [81302550]; Natural Science Foundation of Guangdong Province [S2012040006483]; Science and Technology Planning Project of Guangdong Province [2012B031800031]; SOX7 is a transcription factor mediating various developmental processes. However, its role in hepatocellular carcinoma (HCC) remains unclear. Here, we assessed the role of SOX7 in hepatocarcinogenesis. We found HCC samples exhibited lower levels of SOX7 mRNA and protein expression than non-tumor samples, and the expression of SOX7 was negatively correlated with tumor size. SOX7 expression was also reduced in four HCC cell lines (SMMC-7721, Hep3B, HepG2 and Huh 7). Overexpression of SOX7 could inhibit HCC cell growth, with G1 to S phase arrest. In SOX7-overexpression cells, cyclin D1 and c-myc, two cell cycle promoters, were down-regulated. Moreover, ectopic expression of cyclin D1 or c-myc could override G1 to S pahse arrest induced by SOX7. Furthermore, overexpression of SOX7 suppressed tumor formation with down-regulation of cyclin D1 and c-myc in vivo. The expression of Ki-67, a proliferation marker, was also reduced in SOX7-overexpression tumors. Taken together, our study suggests that SOX7 plays an important inhibitory role in hepatocarcinogenesis, and might be a novel target for HCC therapy.
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93611]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wang, Chong,Guo, Yu,Wang, Jing,et al. The Suppressive Role of SOX7 in Hepatocarcinogenesis[J]. http://dx.doi.org/10.1371/journal.pone.0097433,2014.
APA	Wang, Chong,Guo, Yu,Wang, Jing,Min, Zhiqun,&王翀.(2014).The Suppressive Role of SOX7 in Hepatocarcinogenesis.http://dx.doi.org/10.1371/journal.pone.0097433.
MLA	Wang, Chong,et al."The Suppressive Role of SOX7 in Hepatocarcinogenesis".http://dx.doi.org/10.1371/journal.pone.0097433 (2014).