Characterization of the classical biological false-positive reaction in the serological test for syphilis in the modern era

CORC > 厦门大学 > 医学院－已发表论文

	Characterization of the classical biological false-positive reaction in the serological test for syphilis in the modern era
	Liu, Fan ; Liu, Li-Li ; Guo, Xiao-Jing ; Xi, Ya ; Lin, Li-Rong ; Zhang, Hui-Lin ; Huang, Song-Jie ; Chen, Yu-Yan ; Zhang, Ya-Feng ; Zhang, Qiao ; Huang, Ge-Ling ; Tong, Man-Li ; Jiang, Jie ; Yang, Tian-Ci ; Liu LL(刘莉莉) ; Lin LR(林丽蓉) ; Jiang J(姜杰) ; Yang TC(杨天赐)
刊名	http://dx.doi.org/10.1016/j.intimp.2014.03.011
	2014
关键词	TREPONEMA-PALLIDUM LABORATORY DIAGNOSIS DISEASE IMMUNOASSAY MANAGEMENT ANTIGEN ASSAY
英文摘要	National Natural Science Foundation Major Research Plan [91029729]; National Natural Science Foundation of China [81171625, 81271335, 81201360, 81101324, 811141086, 81201305, 81301501]; Technology Foundation's Major Project of Social Development in Fujian Province [2011Y4009]; Natural Science Foundation of Fujian Province [2012D039]; Dedicated Fund for Shenzhen's Strategic Emerging Industries Development [JCYJ20130327150714488]; Key Projects in Fujian Province Science and Technology Program [2013D025]; projects of Xiamen Science and Technology Program [3502Z20139001, 3502Z20114024]; Key Project of Cultivating Young Talents in Fujian Province's Health System [2013-ZQN-ZD-35]; To characterize the CBFP reaction in the modem era, we analyzed the results of parallel rapid plasma reagin (RPR) and Treponema pallidum particle agglutination (TPPA) tests from a total of 63,765 blood samples obtained at Zhongshan Hospital in the Medical College of Xiamen University from May 2008 to February 2013. Among the 63,765 tested blood samples, 206 (0.32%) had the CBFP reaction. In multivariate analysis, an increased likelihood of the CBFP reaction was associated with female subjects, subjects >= 2.80 years old, and subjects between 16 and 35 years old (P < 0.05). The CBFP reaction occurred in association with 17 categories of disease, including 60 types of diseases, in the 206 subjects. To our knowledge, a number of these diseases had not been previously reported to be associated with the CBFP in the RPR test, including false labor, megaloblastic anemias, aplastic anemias, redundant prepuce, congenital malformation of heart, and salpingitis. Among the 206 patients with the CBFP reaction, 35 patients were subjected to follow-up for five years. 26 out of 35 these patients were at a 1:1 initial RPR titer, 8 out of 35 patients were at a 1:2 initial RPR titer, and 1 out of 35 patients were at a 1:4 initial RPR titer. 30 subjects had their RPR seroreverted. In our opinion, additional CBFP research using a large sample population will contribute to the identification of additional underlying serious disorders that are not related to syphilis. Such results could be useful for the prediction and diagnosis of these diseases. (c) 2014 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93605]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Liu, Fan,Liu, Li-Li,Guo, Xiao-Jing,et al. Characterization of the classical biological false-positive reaction in the serological test for syphilis in the modern era[J]. http://dx.doi.org/10.1016/j.intimp.2014.03.011,2014.
APA	Liu, Fan.,Liu, Li-Li.,Guo, Xiao-Jing.,Xi, Ya.,Lin, Li-Rong.,...&杨天赐.(2014).Characterization of the classical biological false-positive reaction in the serological test for syphilis in the modern era.http://dx.doi.org/10.1016/j.intimp.2014.03.011.
MLA	Liu, Fan,et al."Characterization of the classical biological false-positive reaction in the serological test for syphilis in the modern era".http://dx.doi.org/10.1016/j.intimp.2014.03.011 (2014).