X gene/core promoter deletion mutation: A novel mechanism leading to hepatitis B 'e' antigen-negative chronic hepatitis B

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	X gene/core promoter deletion mutation: A novel mechanism leading to hepatitis B 'e' antigen-negative chronic hepatitis B
	Zhou, Fei ; Xu, Hongzhi ; Chen, Meiya ; Xiao, Hongmin ; Zhang, Zhiping ; Lu, Yapi ; Ren, Jianlin ; Dong, Jing ; Xu HZ(许鸿志) ; Ren JL(任建林)
刊名	http://dx.doi.org/10.3892/mmr.2014.2248
	2014
关键词	HEPATOCELLULAR-CARCINOMA VIRUS PROTEIN REGION GENE IDENTIFICATION REPLICATION MUTANTS ENHANCE BIOLOGY
英文摘要	Xiamen Municipal Fund for major diseases [WKZ0501]; Mutations in the precore and core promoter regions of hepatitis B 'e' antigen (HBeAg) are implicated in HBeAg-negative chronic hepatitis B virus (HBV) infection (CHB). The objective of the current study was to investigate novel mutant patterns that lead to HBeAg-negative CHB. The. PreX-X genomic region from the sera of HBV-infected patients was amplified, and analysis of the sequences displayed a unique deletion region, 234 nucleotides in length, which was observed in 54 clones and named core promoter deletion (CPD). CPD may have an important role in the cause of HBeAg-negative CHB. In addition, a novel deletion mutation in the X gene was observed in patients with CHB. This deletion mutant codes a 76-amino-acid X factor instead of the X protein. In the present study, a new mutation pattern was discovered that may contribute to the cause of HBeAg-negative CHB, and therefore it is worthy of future studies.
语种	英语
出版者	SPANDIDOS PUBL LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93582]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhou, Fei,Xu, Hongzhi,Chen, Meiya,et al. X gene/core promoter deletion mutation: A novel mechanism leading to hepatitis B 'e' antigen-negative chronic hepatitis B[J]. http://dx.doi.org/10.3892/mmr.2014.2248,2014.
APA	Zhou, Fei.,Xu, Hongzhi.,Chen, Meiya.,Xiao, Hongmin.,Zhang, Zhiping.,...&任建林.(2014).X gene/core promoter deletion mutation: A novel mechanism leading to hepatitis B 'e' antigen-negative chronic hepatitis B.http://dx.doi.org/10.3892/mmr.2014.2248.
MLA	Zhou, Fei,et al."X gene/core promoter deletion mutation: A novel mechanism leading to hepatitis B 'e' antigen-negative chronic hepatitis B".http://dx.doi.org/10.3892/mmr.2014.2248 (2014).