Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

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	Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth
	Cheng, Lin ; Huang, Zhi ; Zhou, Wenchao ; Wu, Qiulian ; Donnola, Shannon ; Liu, James K. ; Fang, Xiaoguang ; Sloan, Andrew E. ; Mao, Yubin ; Lathia, Justin D. ; Min, Wang ; McLendon, Roger E. ; Rich, Jeremy N. ; Bao, Shideng ; Mao YB(毛宇彬)
刊名	http://dx.doi.org/10.1016/j.cell.2013.02.021
	2013
关键词	ADHESION MOLECULE-1 PROMOTER PROGENITOR CELLS MESENCHYMAL DIFFERENTIATION REGULATORY ELEMENTS ENDOTHELIAL-CELLS IN-VIVO EXPRESSION BRAIN ANGIOGENESIS ABNORMALITIES
英文摘要	Cleveland Clinic Foundation; National Institutes of Health [NS070315]; Glioblastomas (GBMs) are highly vascular and lethal brain tumors that display cellular hierarchies containing self-renewing tumorigenic glioma stem cells (GSCs). Because GSCs often reside in perivascular niches and may undergo mesenchymal differentiation, we interrogated GSC potential to generate vascular pericytes. Here, we show that GSCs give rise to pericytes to support vessel function and tumor growth. In vivo cell lineage tracing with constitutive and lineage-specific fluorescent reporters demonstrated that GSCs generate the majority of vascular pericytes. Selective elimination of GSC-derived pericytes disrupts the neovasculature and potently inhibits tumor growth. Analysis of human GBM specimens showed that most pericytes are derived from neoplastic cells. GSCs are recruited toward endothelial cells via the SDF-1/CXCR4 axis and are induced to become pericytes predominantly by transforming growth factor beta. Thus, GSCs contribute to vascular pericytes that may actively remodel perivascular niches. Therapeutic targeting of GSC-derived pericytes may effectively block tumor progression and improve antiangiogenic therapy.
语种	英语
出版者	CELL PRESS
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93573]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Cheng, Lin,Huang, Zhi,Zhou, Wenchao,et al. Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth[J]. http://dx.doi.org/10.1016/j.cell.2013.02.021,2013.
APA	Cheng, Lin.,Huang, Zhi.,Zhou, Wenchao.,Wu, Qiulian.,Donnola, Shannon.,...&毛宇彬.(2013).Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth.http://dx.doi.org/10.1016/j.cell.2013.02.021.
MLA	Cheng, Lin,et al."Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth".http://dx.doi.org/10.1016/j.cell.2013.02.021 (2013).