Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth | |
Cheng, Lin ; Huang, Zhi ; Zhou, Wenchao ; Wu, Qiulian ; Donnola, Shannon ; Liu, James K. ; Fang, Xiaoguang ; Sloan, Andrew E. ; Mao, Yubin ; Lathia, Justin D. ; Min, Wang ; McLendon, Roger E. ; Rich, Jeremy N. ; Bao, Shideng ; Mao YB(毛宇彬) | |
刊名 | http://dx.doi.org/10.1016/j.cell.2013.02.021
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2013 | |
关键词 | ADHESION MOLECULE-1 PROMOTER PROGENITOR CELLS MESENCHYMAL DIFFERENTIATION REGULATORY ELEMENTS ENDOTHELIAL-CELLS IN-VIVO EXPRESSION BRAIN ANGIOGENESIS ABNORMALITIES |
英文摘要 | Cleveland Clinic Foundation; National Institutes of Health [NS070315]; Glioblastomas (GBMs) are highly vascular and lethal brain tumors that display cellular hierarchies containing self-renewing tumorigenic glioma stem cells (GSCs). Because GSCs often reside in perivascular niches and may undergo mesenchymal differentiation, we interrogated GSC potential to generate vascular pericytes. Here, we show that GSCs give rise to pericytes to support vessel function and tumor growth. In vivo cell lineage tracing with constitutive and lineage-specific fluorescent reporters demonstrated that GSCs generate the majority of vascular pericytes. Selective elimination of GSC-derived pericytes disrupts the neovasculature and potently inhibits tumor growth. Analysis of human GBM specimens showed that most pericytes are derived from neoplastic cells. GSCs are recruited toward endothelial cells via the SDF-1/CXCR4 axis and are induced to become pericytes predominantly by transforming growth factor beta. Thus, GSCs contribute to vascular pericytes that may actively remodel perivascular niches. Therapeutic targeting of GSC-derived pericytes may effectively block tumor progression and improve antiangiogenic therapy. |
语种 | 英语 |
出版者 | CELL PRESS |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/93573] ![]() |
专题 | 医学院-已发表论文 |
推荐引用方式 GB/T 7714 | Cheng, Lin,Huang, Zhi,Zhou, Wenchao,et al. Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth[J]. http://dx.doi.org/10.1016/j.cell.2013.02.021,2013. |
APA | Cheng, Lin.,Huang, Zhi.,Zhou, Wenchao.,Wu, Qiulian.,Donnola, Shannon.,...&毛宇彬.(2013).Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth.http://dx.doi.org/10.1016/j.cell.2013.02.021. |
MLA | Cheng, Lin,et al."Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth".http://dx.doi.org/10.1016/j.cell.2013.02.021 (2013). |
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