Inhibitory Effect of Neuropilin-1 Monoclonal Antibody (NRP-1 MAb) on Glioma Tumor in Mice

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	Inhibitory Effect of Neuropilin-1 Monoclonal Antibody (NRP-1 MAb) on Glioma Tumor in Mice
	Chen, Lukui ; Miao, Wei ; Tang, Xiaoyong ; Zhang, Haipeng ; Wang, Shengyu ; Luo, Fanghong ; Yan, Jianghua ; Chen LK(陈陆馗) ; Luo FH(罗芳洪) ; Yan JH(颜江华)
刊名	http://dx.doi.org/10.1166/jbn.2013.1623
	2013
关键词	DUAL-COLOR HYBRIDIZATION MAGNETIC NANOPARTICLES ARRAY ENDOTHELIAL GROWTH-FACTOR MESENCHYMAL STEM-CELLS SINGLE-BASE EXTENSION EXPRESSION RECEPTOR CANCER FABRICATION VEGF(165)
英文摘要	Science and Technology Foundation of Fujian Province of China [2011R1039-1]; [NSFC81172970]; This article reports the effect of Neuropilin-1 monoclonal antibody (NRP-1 MAb) on glioma cell lines in vitro and the effect on nude mice bearing glioma tumor (U87) in vivo. MTT, the scratch test and transwell test were used to evaluate the inhibitory effect of NRP-1 MAb on glioma cell lines. The tissue distribution and tumor targeting capability of NRP-1 MAb in U87 Xenografts nude mice was determined in Optical Imaging. Anti-glioma experiment was carried out by NRP-1 MAb on U87 Xenografts nude mice. NRP-1 MAb was showed to inhibit the proliferation, migration and invasion of glioma cells. NRP-1 MAb can specifically target the tumor in U87 Xenografts nude mice and reduce the proliferation activity of the tumor. The results of this study indicate that NRP-1 MAb can inhibit the proliferation, migration and metastasis of glioma cell lines and can target the glioma tumor to reduce tumor growth. Therefore, NRP-1 MAb may be an effective agent for glioma-targeted therapy.
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93562]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Chen, Lukui,Miao, Wei,Tang, Xiaoyong,et al. Inhibitory Effect of Neuropilin-1 Monoclonal Antibody (NRP-1 MAb) on Glioma Tumor in Mice[J]. http://dx.doi.org/10.1166/jbn.2013.1623,2013.
APA	Chen, Lukui.,Miao, Wei.,Tang, Xiaoyong.,Zhang, Haipeng.,Wang, Shengyu.,...&颜江华.(2013).Inhibitory Effect of Neuropilin-1 Monoclonal Antibody (NRP-1 MAb) on Glioma Tumor in Mice.http://dx.doi.org/10.1166/jbn.2013.1623.
MLA	Chen, Lukui,et al."Inhibitory Effect of Neuropilin-1 Monoclonal Antibody (NRP-1 MAb) on Glioma Tumor in Mice".http://dx.doi.org/10.1166/jbn.2013.1623 (2013).