Amygdalin inhibits renal fibrosis in chronic kidney disease

CORC > 厦门大学 > 医学院－已发表论文

	Amygdalin inhibits renal fibrosis in chronic kidney disease
	Guo, Junqi ; Wu, Weizheng ; Sheng, Mingxiong ; Yang, Shunliang ; Tan, Jianming ; Yang SL(杨顺良) ; Tan JM(谭建明)
刊名	http://dx.doi.org/10.3892/mmr.2013.1391
	2013
关键词	MESENCHYMAL TRANSITION MECHANISMS CELLS FIBROGENESIS FIBROBLASTS EXPRESSIONS INSIGHTS INJURY
英文摘要	Key Laboratory of Fujian Province [2008J1006]; Nanjing Medical Technology Innovation Project, China [2009MA093]; Renal interstitial fibrosis is a common outcome of chronic renal diseases. Amygdalin is one of a number of nitrilosides, the natural cyanide-containing substances abundant in the seeds of plants of the prunasin family that are used to treat cancer and relieve pain. However, whether amygdalin inhibits the progression of renal fibrosis or not remains unknown. The present study aimed to assess the therapeutic posential of amygdalin by investigating its effect and potential mechanism on the activation of renal interstitial fibroblast cells and renal fibrosis in rat unilateral ureteral obstruction (UUO). Treatment of the cultured renal interstitial fibroblasts with amygdalin inhibited their proliferation and the production of transforming growth factor (TGF)-beta 1. In the rat model of obstructive nephropathy, following ureteral obstruction, the administration of amygdalin immediately eliminated the extracellular matrix accumulation and alleviated the renal injury on the 21st day. Collectively, amygdalin attenuated kidney fibroblast (KFB) activation and rat renal interstitial fibrosis. These results indicate that amygdalin is a potent antifibrotic agent that may have therapeutic potential for patients with fibrotic kidney diseases.
语种	英语
出版者	SPANDIDOS PUBL LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93548]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Guo, Junqi,Wu, Weizheng,Sheng, Mingxiong,et al. Amygdalin inhibits renal fibrosis in chronic kidney disease[J]. http://dx.doi.org/10.3892/mmr.2013.1391,2013.
APA	Guo, Junqi.,Wu, Weizheng.,Sheng, Mingxiong.,Yang, Shunliang.,Tan, Jianming.,...&谭建明.(2013).Amygdalin inhibits renal fibrosis in chronic kidney disease.http://dx.doi.org/10.3892/mmr.2013.1391.
MLA	Guo, Junqi,et al."Amygdalin inhibits renal fibrosis in chronic kidney disease".http://dx.doi.org/10.3892/mmr.2013.1391 (2013).