ROS1 fusions in Chinese patients with non-small-cell lung cancer

CORC > 厦门大学 > 医学院－已发表论文

	ROS1 fusions in Chinese patients with non-small-cell lung cancer
	Cai, W. ; Li, X. ; Su, C. ; Fan, L. ; Zheng, L. ; Fei, K. ; Zhou, C. ; Manegold, C. ; Schmid-Bindert, G. ; Li X(黎新) ; Zheng L(郑林)
刊名	http://dx.doi.org/10.1093/annonc/mdt071
	2013
关键词	ANAPLASTIC LYMPHOMA KINASE RECEPTOR TYROSINE KINASE GENE ADENOCARCINOMA IDENTIFICATION REARRANGEMENT LANDSCAPE GEFITINIB TUMORS
英文摘要	National Natural Science Foundation of China [81172101]; Science and Techology Commission of Shanghai Municipality [11JC1411301]; Background: To determine the prevalence and clinicopathological features of ROS1 fusions in Chinese patients with non-small-cell lung cancer (NSCLC). Methods: Formalin-fixed and paraffin-embedded (FFPE) tissue sections from 392 patients with NSCLC were screened for ROS1 fusions by multiplex RT-PCR and all ROS1 fusions were validated by direct sequencing. The relationship between ROS1 fusions and clinicopathological features and the prognostic effect of the ROS1 fusion status on survival were analyzed. Results: In this study, 8 of 392 (2.0%) evaluable samples were found to harbor ROS1 fusions. Of the ROS1-positive patients, seven presented with adenocarcinoma, and one with adenosquamous carcinoma. The ratio of female to male and never smoker to smokers in a ROS1 fusion-positive group was 5:3. There was no statistically significant difference in age, sex, smoking history, histological type and pathological stage between ROS1 fusion-positive and ROS1 fusion-negative patients. ROS1 fusion-negative patients had a significantly longer survival when compared with ROS1 fusion-positive patients (P = 0.041). Lower pathological stage, younger age and ROS1 fusion-negative status were significantly associated with better prognosis on multivariate analysis. Conclusions: ROS1 fusions occurred in similar to 2.0% of Chinese patients with NSCLC and had no specific clinicopathological feature. ROS1 fusion-negative patients may have a better survival than ROS1 fusion-positive patients.
语种	英语
出版者	OXFORD UNIV PRESS
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93527]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Cai, W.,Li, X.,Su, C.,et al. ROS1 fusions in Chinese patients with non-small-cell lung cancer[J]. http://dx.doi.org/10.1093/annonc/mdt071,2013.
APA	Cai, W..,Li, X..,Su, C..,Fan, L..,Zheng, L..,...&郑林.(2013).ROS1 fusions in Chinese patients with non-small-cell lung cancer.http://dx.doi.org/10.1093/annonc/mdt071.
MLA	Cai, W.,et al."ROS1 fusions in Chinese patients with non-small-cell lung cancer".http://dx.doi.org/10.1093/annonc/mdt071 (2013).