The Regulating Function of Heterotrimeric G Proteins in the Immune System

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	The Regulating Function of Heterotrimeric G Proteins in the Immune System
	Wang, Yantang ; Li, Yan ; Shi, Guixiu ; Shi GX(石桂秀)
刊名	http://dx.doi.org/10.1007/s00005-013-0230-5
	2013
关键词	INFLAMMATORY-BOWEL-DISEASE G-ALPHA-I T-CELL PERTUSSIS-TOXIN G-ALPHA-I2-DEFICIENT MICE SIGNALING PATHWAYS CHEMOKINE RECEPTORS CYTOKINE PRODUCTION ULCERATIVE-COLITIS DENDRITIC CELLS
英文摘要	National Natural Science Foundation of China (NSFC) [30830094, 30972678]; Heterotrimeric guanine nucleotide-binding proteins (G proteins), which consist of an alpha-, a beta- and a gamma-subunit, have crucial roles as molecular switches in the regulation of the downstream effector molecules of multiple G protein-coupled receptor signalling pathways, such as phospholipase C and adenylyl cyclase. According to the structural and functional similarities of their alpha-subunits, G proteins can be divided into four subfamilies: G alpha s, G alpha i/o, G alpha q/11 and G alpha 12/13. Most of the alpha- and the beta gamma-subunits are abundantly expressed on the surface of immune cells. Recent studies have demonstrated that G proteins are a group of important immunomodulatory factors that regulate the migration, activation, survival, proliferation, differentiation and cytokine secretion of immune cells. In this review, we summarise the recent findings on the functions of G proteins in immune regulation and autoimmunity.
语种	英语
出版者	SPRINGER BASEL AG
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93516]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wang, Yantang,Li, Yan,Shi, Guixiu,et al. The Regulating Function of Heterotrimeric G Proteins in the Immune System[J]. http://dx.doi.org/10.1007/s00005-013-0230-5,2013.
APA	Wang, Yantang,Li, Yan,Shi, Guixiu,&石桂秀.(2013).The Regulating Function of Heterotrimeric G Proteins in the Immune System.http://dx.doi.org/10.1007/s00005-013-0230-5.
MLA	Wang, Yantang,et al."The Regulating Function of Heterotrimeric G Proteins in the Immune System".http://dx.doi.org/10.1007/s00005-013-0230-5 (2013).