FoxO3a and nilotinib-induced erythroid differentiation of CML-BC cells

CORC > 厦门大学 > 医学院－已发表论文

	FoxO3a and nilotinib-induced erythroid differentiation of CML-BC cells
	Wang, Wei ; Li, Nan-Nan ; Du, Yan ; Lv, Fei-Fei ; Lin, Guo-Qiang ; Wang W(王玮)
刊名	http://dx.doi.org/10.1016/j.leukres.2013.07.001
	2013
关键词	CHRONIC MYELOID-LEUKEMIA CHRONIC MYELOGENOUS-LEUKEMIA HEMATOPOIETIC STEM-CELLS CYTOGENETIC RESPONSES SIGNALING PATHWAYS POINT MUTATIONS BLAST CRISIS IMATINIB ABL KINASE
英文摘要	We explored the potential involvement of FoxO3a activation in erythroid and granulocytic differentiation for Ph+ cells of chronic myeloid leukemia blast crisis (CML BC). We demonstrate that FoxO3a activation in CML blast crisis (BC) cells by overexpressing FoxO3a leads to the maturation of CML BC cells. Hemoglobin production significantly increased upon FoxO3a activation in CML BC cells. FoxO3a activation upregulated erythroid surface protein (glycophorin A, GPA), but did not significantly modulate granulocytic markers (CD11b). Additionally, FoxO3a activation reduced the mRNA and protein expression of Tal1. Similar results were observed in cells that were given nilotinib. Our results indicate that FoxO3a activation may promote erythroid differentiation of BC cells via down-regulating Tal1 expression. (C) 2013 Elsevier Ltd. All rights reserved.
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93488]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wang, Wei,Li, Nan-Nan,Du, Yan,et al. FoxO3a and nilotinib-induced erythroid differentiation of CML-BC cells[J]. http://dx.doi.org/10.1016/j.leukres.2013.07.001,2013.
APA	Wang, Wei,Li, Nan-Nan,Du, Yan,Lv, Fei-Fei,Lin, Guo-Qiang,&王玮.(2013).FoxO3a and nilotinib-induced erythroid differentiation of CML-BC cells.http://dx.doi.org/10.1016/j.leukres.2013.07.001.
MLA	Wang, Wei,et al."FoxO3a and nilotinib-induced erythroid differentiation of CML-BC cells".http://dx.doi.org/10.1016/j.leukres.2013.07.001 (2013).