Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription

CORC > 厦门大学 > 医学院－已发表论文

	Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription
	Xu, Bin ; Li, Shan-Hua ; Zheng, Rong ; Gao, Shu-Bin ; Ding, Li-Hong ; Yin, Zhen-Yu ; Lin, Xiao ; Feng, Zi-Jie ; Zhang, Sheng ; Wang, Xiao-Min ; Jin, Guang-Hui ; Xu B(徐斌) ; Li SH(李善花) ; Zheng R(郑荣) ; Ding LH(丁丽红) ; Yin ZY(尹震宇) ; Feng ZJ(冯子杰) ; Jin GH(金光辉)
刊名	http://dx.doi.org/10.1073/pnas.1312022110
	2013
关键词	MULTIPLE ENDOCRINE NEOPLASIA TUMOR-SUPPRESSOR LUNG ADENOCARCINOMA LIVER-CANCER CARCINOMA GENE GROWTH MLL IDENTIFICATION MUTATIONS
英文摘要	Natural Science Foundation of China [91229111, 81272719, 81101924, 81101763]; Natural Science Foundation of Fujian Province [2011J06016]; Natural Science Foundation of Xiamen [3502Z20104001]; Menin is a scaffold protein encoded by the multiple endocrine neoplasia type 1 (MEN1) gene in humans, and it interacts with a variety of transcriptional proteins to control active or repressive cellular processes. Here, we show that heterozygous ablation of Men1 in female mice reduces chemical carcinogen-induced liver carcinogenesis and represses the activation of the inflammation pathway. Using ChIP-on-chip screens and ChIP assays, we find that menin occupancy frequently coincides with H3K4me3 at the promoter of many liver cancer-related genes, such as Yes-associated protein (Yap1). Increased menin and Yap1 expression in human hepatocellular carcinoma specimens was associated with poor prognosis. Our findings reveal that menin plays an important epigenetic role in promoting liver tumorigenesis, and support the notion that H3K4me3, which is regulated by the menin-mixed-lineage leukemia complex, is a potential therapeutic target in hepatocellular carcinoma.
语种	英语
出版者	NATL ACAD SCIENCES
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93469]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Xu, Bin,Li, Shan-Hua,Zheng, Rong,et al. Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription[J]. http://dx.doi.org/10.1073/pnas.1312022110,2013.
APA	Xu, Bin.,Li, Shan-Hua.,Zheng, Rong.,Gao, Shu-Bin.,Ding, Li-Hong.,...&金光辉.(2013).Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.http://dx.doi.org/10.1073/pnas.1312022110.
MLA	Xu, Bin,et al."Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription".http://dx.doi.org/10.1073/pnas.1312022110 (2013).