Weak link of tendon-bone healing and a control experiment to promote healing

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	Weak link of tendon-bone healing and a control experiment to promote healing
	Zhai, Wenliang ; Lv, Chenwei ; Zheng, Yanmei ; Gao, Yuechuan ; Ding, Zhenqi ; Chen, Zhiwen ; Zhai WL(翟文亮) ; Ding ZQ(丁真奇) ; Chen ZW(陈志文)
刊名	http://dx.doi.org/10.1007/s00402-013-1802-x
	2013
关键词	PLATELET-RICH PLASMA ANTERIOR CRUCIATE LIGAMENT TISSUE REGENERATION PATELLAR TENDON TUNNEL PROTEINS RECONSTRUCTION AUGMENTATION TGF-BETA-1 RABBITS
英文摘要	This study aims to observe the mechanical weak point and histological features of tendon-bone interface after anterior cruciate ligament reconstructive surgery and to explore the tendon-bone healing effects of the platelet-rich gel (PRG) + deproteinized bone (DPB) compound. A total of 48 New Zealand white rabbits were randomly divided into normal group, model (without embedding), experimental (embedded with the PRG + DPB compound), and control (embedded with DPB) groups. The rabbits were executed at 2, 4, 8, and 12 weeks after the operation. Then, micro-computed tomography scan and uniaxial tensile test were conducted. The fractured specimens were subjected to histological observation. At 4, 8, and 12 weeks after the operation, the bone density of the tendon-bone bound section of the experimental group was higher than that of the other groups (P < 0.05). At 4 and 8 weeks, the maximum tensile load of the experimental group was obviously higher than that of the control and model groups (P < 0.05). Histological observation indicated that the tendon-bone interface in the experimental group had more cartilage and bone tissue growing toward the internal tendon, but the fracture layer mainly occurred in the non-ankylosed part. The mechanical weak point of the early tendon-bone interface was in the immature fibrous tissue. The PRG + DPB compound can effectively trigger tendon-bone healing by promoting the maturation and ossification of the tendon-bone tissue. This compound improved the tensile strength of the healing interface and reduced bone tunnel enlargement.
语种	英语
出版者	SPRINGER
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93464]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhai, Wenliang,Lv, Chenwei,Zheng, Yanmei,et al. Weak link of tendon-bone healing and a control experiment to promote healing[J]. http://dx.doi.org/10.1007/s00402-013-1802-x,2013.
APA	Zhai, Wenliang.,Lv, Chenwei.,Zheng, Yanmei.,Gao, Yuechuan.,Ding, Zhenqi.,...&陈志文.(2013).Weak link of tendon-bone healing and a control experiment to promote healing.http://dx.doi.org/10.1007/s00402-013-1802-x.
MLA	Zhai, Wenliang,et al."Weak link of tendon-bone healing and a control experiment to promote healing".http://dx.doi.org/10.1007/s00402-013-1802-x (2013).