Optimal treatment opportunity for mTHPC-mediated photodynamic therapy of liver cancer

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	Optimal treatment opportunity for mTHPC-mediated photodynamic therapy of liver cancer
	Wang, Jian-dong ; Shen, Jun ; Zhou, Xue-ping ; Shi, Wei-bin ; Yan, Jiang-hua ; Luo, Fang-hong ; Quan, Zhi-wei ; Yan JH(颜江华) ; Luo FH(罗芳洪)
刊名	http://dx.doi.org/10.1007/s10103-012-1248-3
	2013
关键词	TUMOR-MODEL IN-VIVO PHARMACOKINETICS TISSUE PHOTOSENSITIZER BIODISTRIBUTION EFFICACY QUANTIFICATION TEMOPORFIN EFFICIENCY
英文摘要	National "Eleventh Five-Year" special science and technology major project [2008ZX10002-025]; College Fund of Shanghai Jiaotong University School of Medicine [10XJ22003]; Photodynamic therapy (PDT) has been clinically used for liver cancer. The pharmacokinetics of a photosensitizer needs to be monitored so that PDT can be performed at the most favorable time and with the proper dose to increase the cure rate. As mTHPC is a fluorescent compound, we investigate its pharmacokinetics, distribution, and elimination in the rat orthotropic liver cancer model in order to confirm an optimal treatment opportunity of liver cancer PDT. After intravenous administration at a single dose of 300 mu g/kg, mTHPC was extracted from tissue homogenates or plasma. Then, mTHPC concentrations were assessed by fluorescence spectroscopy and the data were processed with PK-GRAPH pharmacokinetic procedure. The plasma concentration-time profile of mTHPC showed a short distribution half-life (TA1/2I +/- = 0.082 h) and a relatively longer elimination half-life (TA1/2I(2) = 28.23 h), which quite fitted with a two-compartment model. The results of mTHPC tissue distributions showed that the highest drug accumulation was in tumor tissue, and successively decreased in liver, heart, spleen, muscle, and skin tissues. The drug distribution ratio of tumor to normal tissue reached the peak at 24 h after mTHPC administration. mTHPC was eliminated at a suitable rate in rat orthotropic liver cancer model, and there was no long-term accumulation of mTHPC in rat tissues. For PDT of orthotropic liver cancer, 24 h after mTHPC intravenous injection may be the optimal treatment time point, which might provide higher clinical efficacy and reduce side effects.
语种	英语
出版者	SPRINGER LONDON LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93463]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wang, Jian-dong,Shen, Jun,Zhou, Xue-ping,et al. Optimal treatment opportunity for mTHPC-mediated photodynamic therapy of liver cancer[J]. http://dx.doi.org/10.1007/s10103-012-1248-3,2013.
APA	Wang, Jian-dong.,Shen, Jun.,Zhou, Xue-ping.,Shi, Wei-bin.,Yan, Jiang-hua.,...&罗芳洪.(2013).Optimal treatment opportunity for mTHPC-mediated photodynamic therapy of liver cancer.http://dx.doi.org/10.1007/s10103-012-1248-3.
MLA	Wang, Jian-dong,et al."Optimal treatment opportunity for mTHPC-mediated photodynamic therapy of liver cancer".http://dx.doi.org/10.1007/s10103-012-1248-3 (2013).