Phenylpropanoid glycoside inhibition of pepsin, trypsin and alpha-chymotrypsin enzyme activity in Kudingcha leaves from Ligustrum purpurascens

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	Phenylpropanoid glycoside inhibition of pepsin, trypsin and alpha-chymotrypsin enzyme activity in Kudingcha leaves from Ligustrum purpurascens
	Wu, Xuli ; Wang, WenPu ; Zhu, Tian ; Liang, Ting ; Lu, FangQi ; He, Weiyi ; Zhang, Haiping ; Liu, Zhigang ; He, ShaoHeng ; Gao, Kaiping ; He, Zhendan ; Zhang HP(张海萍)
刊名	http://dx.doi.org/10.1016/j.foodres.2013.10.020
	2013
关键词	BETA-LACTOGLOBULIN GREEN TEA POLYPHENOL ROBUSTUM ACTEOSIDE BINDING
英文摘要	Natural Science Funding of Shenzhen University [801-00035911]; Natural Science Funding of Guangdong Province [S2012010008514, S2013010016791]; Shenzhen Funding for Technology Development Project [CXZZ20130320165017541, SW201110010, JCYJ20130326110246234]; Phenylpropanoid glycosides (PPGs) are important ingredients in Kudingcha bitter tea from Ligustrum purpurascens, possessing many beneficial properties. Here, we investigated the effect of PPGs on the activity of the digestive enzymes pepsin, trypsin and alpha-chymotrypsin. Furthermore, we explored the interactions between PPGs and digestive enzymes by a multi-spectroscopic method and docking studies. PPGs could inhibit digestive enzyme activities with a non-competitive pattern of inhibition. PPGs may have a binding effect on these digestive enzymes, changing the polarity and the structure of enzymes, which results in decreased enzyme activity. This description of the effects of PPG inactivation of pepsin, trypsin and alpha-chymotrypsin helps reveal the potential anti-nutritional property of PPGs. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93416]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wu, Xuli,Wang, WenPu,Zhu, Tian,et al. Phenylpropanoid glycoside inhibition of pepsin, trypsin and alpha-chymotrypsin enzyme activity in Kudingcha leaves from Ligustrum purpurascens[J]. http://dx.doi.org/10.1016/j.foodres.2013.10.020,2013.
APA	Wu, Xuli.,Wang, WenPu.,Zhu, Tian.,Liang, Ting.,Lu, FangQi.,...&张海萍.(2013).Phenylpropanoid glycoside inhibition of pepsin, trypsin and alpha-chymotrypsin enzyme activity in Kudingcha leaves from Ligustrum purpurascens.http://dx.doi.org/10.1016/j.foodres.2013.10.020.
MLA	Wu, Xuli,et al."Phenylpropanoid glycoside inhibition of pepsin, trypsin and alpha-chymotrypsin enzyme activity in Kudingcha leaves from Ligustrum purpurascens".http://dx.doi.org/10.1016/j.foodres.2013.10.020 (2013).