Polymorphism of the RAGE Affects the Serum Inflammatory Levels and Risk of Ischemic Stroke in a Chinese Population

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	Polymorphism of the RAGE Affects the Serum Inflammatory Levels and Risk of Ischemic Stroke in a Chinese Population
	Cui, XiaoPing ; Chen, HongJie ; Hou, Xuwei ; Wang, ShouSen ; Jayaram, Shoba ; Zheng, ZhaoCong ; Wang SS(王守森)
刊名	http://dx.doi.org/10.1159/000354494
	2013
关键词	GLYCATION END-PRODUCTS C-REACTIVE PROTEIN PLASMINOGEN-ACTIVATOR INHIBITOR-1 CORONARY-ARTERY-DISEASE GENE POLYMORPHISMS GLY82SER POLYMORPHISM DIABETIC-RETINOPATHY ASSOCIATION ANALYSIS CIRCULATING LEVELS CEREBRAL-ISCHEMIA
英文摘要	Background: Increasing evidence shows that inflammation plays an important role in the occurrence and progression of acute ischemic stroke. The receptor for advanced glycation end products (RAGE) has been documented to involve in the pathogenic mechanisms of a variety of neurological diseases, including ischemic stroke (IS). However, the impact of RAGE gene polymorphisms on the susceptibility to IS has not been reported. We thus explored the association between RAGE gene polymorphisms and the susceptibility to IS. Method: A total of 384 patients with IS and 425 healthy controls were enrolled in this study. Three genetic polymorphisms of RAGE gene (82G/S, -429T/C and -374T/A) were determined. The serum levels of soluble RAGE (sRAGE), intetleukin-6 (IL-6), high sensitivity-C reaction protein (hsCRP) and plasminogen activator inhibitor-1 (PAT-1) were detected. Results: Among the studied polymorphisms, only the polymorphism at 82G/S of RAGE gene was associated with the risk for ischemic stroke irrespective of the stroke subtypes. The 82S/S homozygote carriers had a significantly increased risk for ischemic stroke [adjusted odds ratio (OR): 2.297; p<0.001]. The haplotype analyses showed that the C 429S821- 374 and T 429SuA 374 had higher risk to develop IS (OR=1.864 and 1.931, respectively, all p <0.01), while the C 429G82T 374showed a protective effect against IS susceptibility (OR=0.568, p=0.001). In addition, the 82S/S homozygote carriers had a higher inflammatory level compared with 82G/S and 82G/G genotypes, indicated by lower serum sRAGE level, higher serum IL-6, hs-CRP and PAT-1 levels. The polymorphisms at -374 and -429 loci did not influence the stroke risk and the above mentioned inflammation cytokines. Conclusion: Our results showed a close correlation between the 82G/S polymorphism and the susceptibility to IS, suggesting the 82G/S polymorphism may be used as a genetic marker for the prediction of stroke occurrence in high risk subjects. Copyright (C) 2013 S. Karger AG, Basel
语种	英语
出版者	KARGER
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93412]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Cui, XiaoPing,Chen, HongJie,Hou, Xuwei,et al. Polymorphism of the RAGE Affects the Serum Inflammatory Levels and Risk of Ischemic Stroke in a Chinese Population[J]. http://dx.doi.org/10.1159/000354494,2013.
APA	Cui, XiaoPing.,Chen, HongJie.,Hou, Xuwei.,Wang, ShouSen.,Jayaram, Shoba.,...&王守森.(2013).Polymorphism of the RAGE Affects the Serum Inflammatory Levels and Risk of Ischemic Stroke in a Chinese Population.http://dx.doi.org/10.1159/000354494.
MLA	Cui, XiaoPing,et al."Polymorphism of the RAGE Affects the Serum Inflammatory Levels and Risk of Ischemic Stroke in a Chinese Population".http://dx.doi.org/10.1159/000354494 (2013).