Risk factors for No 12p and No 12b lymph node metastases in advanced gastric cancer in China

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	Risk factors for No 12p and No 12b lymph node metastases in advanced gastric cancer in China
	Feng, Ji-Feng ; Huang, Ying ; Liu, Jing ; Liu, Huang ; Sheng, Hua-Ying ; Wei, Wei-Tian ; Lu, Wei-Shan ; Chen, Da-Feng ; Chen, Wen-You ; Zhou, Xing-Ming ; Liu J(刘静)
刊名	http://dx.doi.org/10.3109/03009734.2012.729103
	2013
关键词	PROGNOSTIC-SIGNIFICANCE D2 GASTRECTOMY SURGICAL TRIAL MORBIDITY MORTALITY LYMPHADENECTOMY CARCINOMA SURGERY MULTICENTER DISSECTION
英文摘要	Background. The risk factors for No. 12p and No. 12b lymph node (LN) metastases in advanced gastric cancer (GC) remain controversial. The aim of this study was to investigate the risk factors for No. 12p and No. 12b LN metastases in advanced GC. Methods. From January 1999 to December 2005, a retrospective analysis of 163 patients with advanced GC who underwent D2 lymphadenectomy in addition to No. 12p and No. 12b LN dissections was conducted. Potential clinicopathological factors that could influence No. 12p and No. 12b LN metastases were statistically analyzed. Results. There were 15 cases (9.2%) with No. 12p LN metastases and 5 cases (3.1%) with synchronous No. 12b LN metastases. A logistic regression analysis revealed that the Borrmann type (III/IV versus I/II, P = 0.029), localization (lesser/circular versus greater, P = 0.025), and depth of invasion (pT4 versus pT2/pT3, P = 0.009) were associated with 11.1-, 3.8-, and 5.6-fold increases, respectively, for risk of No. 12p and No. 12b LN metastases. A logistic regression analysis also showed that No. 5 (P = 0.006) and No. 12a (P = 0.004) LN metastases were associated with 6.9- and 11.3-fold increases, respectively, for risk of No. 12p and No. 12b LN metastases. In addition, significant differences in 5-year survival of patients with and without No. 12p and No. 12b LN metastases were observed (13.3% versus 35.1%, P = 0.022). Conclusion. We conclude that Borrmann type, localization, and depth of invasion are significant variables for identifying patients with No. 12p and No. 12b LN metastases. Individuals with No. 5 or No. 12a LN metastases should be on high alert for the possibility of additional metastases to the No. 12p and No. 12b LNs.
语种	英语
出版者	INFORMA HEALTHCARE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93394]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Feng, Ji-Feng,Huang, Ying,Liu, Jing,et al. Risk factors for No 12p and No 12b lymph node metastases in advanced gastric cancer in China[J]. http://dx.doi.org/10.3109/03009734.2012.729103,2013.
APA	Feng, Ji-Feng.,Huang, Ying.,Liu, Jing.,Liu, Huang.,Sheng, Hua-Ying.,...&刘静.(2013).Risk factors for No 12p and No 12b lymph node metastases in advanced gastric cancer in China.http://dx.doi.org/10.3109/03009734.2012.729103.
MLA	Feng, Ji-Feng,et al."Risk factors for No 12p and No 12b lymph node metastases in advanced gastric cancer in China".http://dx.doi.org/10.3109/03009734.2012.729103 (2013).