In situ forming chitosan/hydroxyapatite rods reinforced via genipin crosslinking

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	In situ forming chitosan/hydroxyapatite rods reinforced via genipin crosslinking
	Pu, Xi-ming ; Wei, Kai ; Zhang, Qi-qing ; Zhang QQ(张其清)
刊名	http://dx.doi.org/10.1016/j.matlet.2012.12.009
	2013
关键词	CHITOSAN FABRICATION HYDROXYAPATITE/CHITOSAN NANOPARTICLES MEMBRANE FIXATION FRACTURE
英文摘要	National Key Technologies R & D Program of China [2007BAD07B05, 2012BAI7B03]; Major Research Plan of Fujian Province [2010NZ0001-1]; Major Research Plan of the National Nature Science Foundation of China [90923042]; Key Project of Fujian Provincial Department of Ocean and Fisheries, China [2008 1-11]; Chitosan/hydroxyapatite composite rods are good candidates as temporary mechanical supports in bone regeneration; however the mechanical properties of this kind of materials should be improved. In this work, chitosan/hydroxyapatite composite rods with multilayer structure were reinforced using a bio-crosslinker to improve their mechanical properties and anti-degradation ability. The SEM results revealed that the composite rods had a tree-ring structure. The bending strength and bending modulus of the crosslinked rods could arrive at 161 MPa and 7.2 GPa, respectively, increased by 59.4% and 26.3% compared with uncrosslinked ones (p < 0.05). The enzymatic degradation studies indicated that genipin crosslinking could effectively enhance the biostability of the composite rods. Consequently, genipin-crosslinked chitosan/hydroxyapatite composite rods with excellent mechanical properties would be a novel device used for internal fixation of bone fracture. (C) 2012 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93393]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Pu, Xi-ming,Wei, Kai,Zhang, Qi-qing,et al. In situ forming chitosan/hydroxyapatite rods reinforced via genipin crosslinking[J]. http://dx.doi.org/10.1016/j.matlet.2012.12.009,2013.
APA	Pu, Xi-ming,Wei, Kai,Zhang, Qi-qing,&张其清.(2013).In situ forming chitosan/hydroxyapatite rods reinforced via genipin crosslinking.http://dx.doi.org/10.1016/j.matlet.2012.12.009.
MLA	Pu, Xi-ming,et al."In situ forming chitosan/hydroxyapatite rods reinforced via genipin crosslinking".http://dx.doi.org/10.1016/j.matlet.2012.12.009 (2013).