ECHS1 acts as a novel HBsAg-binding protein enhancing apoptosis through the mitochondrial pathway in HepG2 cells

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	ECHS1 acts as a novel HBsAg-binding protein enhancing apoptosis through the mitochondrial pathway in HepG2 cells
	Xiao, Chuan-Xing ; Yang, Xiao-Ning ; Huang, Qing-Wen ; Zhang, Yu-Qin ; Lin, Bi-Yun ; Liu, Jing-Jing ; Liu, Yun-Peng ; Jazag, Arnarsanaa ; Guleng, Bayasi ; Ren, Jian-Lin ; Ren JL(任建林)
刊名	http://dx.doi.org/10.1016/j.canlet.2012.11.030
	2013
关键词	HEPATITIS-B-VIRUS HEPATOCELLULAR-CARCINOMA ENOYL-COENZYME PROTEOMIC ANALYSIS GENE-EXPRESSION LIVER-DISEASE SHORT-CHAIN C-VIRUS HEPATOCYTES BAX
英文摘要	National Natural Science Foundation of China [30971362, 81072013]; Fundamental Research Funds for the Central Universities in China [2010111082]; Key Projects for the Technology Plan of Fujian Province in China [2009D020]; Foundations of Health Bureau of Fujian and Xiamen in China [2007CXB8, 3502z20077046]; We aimed to confirm the role of ECHS1 as a binding protein of HBsAg (HBs) and investigate its function during the development of hepatocellular carcinoma (HCC). Our results show that both exogenous and endogenous ECHS1 proteins bind to HBs and co-localize in the cytoplasm in vitro. The coexistence of HBs and ECHS1 enhances HepG2 cell apoptosis, affects ECHS1 localization in the mitochondria and induces apoptosis by decreasing the mitochondrial membrane potential (MMP). These findings suggest that ECHS1 may be applied as a potential therapeutic target during the treatment of HBV-related hepatitis or HCC. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
语种	英语
出版者	ELSEVIER IRELAND LTD
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93390]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Xiao, Chuan-Xing,Yang, Xiao-Ning,Huang, Qing-Wen,et al. ECHS1 acts as a novel HBsAg-binding protein enhancing apoptosis through the mitochondrial pathway in HepG2 cells[J]. http://dx.doi.org/10.1016/j.canlet.2012.11.030,2013.
APA	Xiao, Chuan-Xing.,Yang, Xiao-Ning.,Huang, Qing-Wen.,Zhang, Yu-Qin.,Lin, Bi-Yun.,...&任建林.(2013).ECHS1 acts as a novel HBsAg-binding protein enhancing apoptosis through the mitochondrial pathway in HepG2 cells.http://dx.doi.org/10.1016/j.canlet.2012.11.030.
MLA	Xiao, Chuan-Xing,et al."ECHS1 acts as a novel HBsAg-binding protein enhancing apoptosis through the mitochondrial pathway in HepG2 cells".http://dx.doi.org/10.1016/j.canlet.2012.11.030 (2013).