Predictive value of breast cancer molecular subtypes in Chinese patients with four or more positive nodes after postmastectomy radiotherapy

CORC > 厦门大学 > 医学院－已发表论文

	Predictive value of breast cancer molecular subtypes in Chinese patients with four or more positive nodes after postmastectomy radiotherapy
	Wu, San-Gang ; He, Zhen-Yu ; Li, Qun ; Li, Feng-Yan ; Lin, Qin ; Lin, Huan-Xin ; Guan, Xun-Xing ; Lin Q(林勤)
刊名	http://dx.doi.org/10.1016/j.breast.2012.07.004
	2012-10
关键词	POSTOPERATIVE RADIOTHERAPY LOCOREGIONAL RECURRENCE ADJUVANT CHEMOTHERAPY PROGESTERONE-RECEPTOR ESTROGEN-RECEPTOR COOPERATIVE-GROUP RANDOMIZED-TRIAL RISK THERAPY RADIATION
英文摘要	Sci-Tech Office of Guangdong Province [2008B060600019]; The molecular subtypes of breast cancer based on status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (Her2) expression are associated with markedly different clinical outcomes. We retrospectively analyzed 774 breast cancer patients with four or more positive nodes, who underwent mastectomy between March 1999 and December 2007. Treatment with postmastectomy radiotherapy (PMRT) reduced the rates of locoregional recurrence-free survival (LRFS; 6.7% vs. 26.6%), distant metastasis-free survival (DMFS; 26.9% vs. 50.0%), and mortality (24.4% vs. 45.3%) for luminal-A subtypes (ER+ or PR+, Her2-) and reduced LRFS (12.1% vs. 27.5%) for the luminal-B subtype (ER+ or PR+, Her2+) compared with patients not receiving PMRT. However, PMRT did not affect the endpoints for the Her2-enriched or basal subtypes. Thus, understanding the differences in patterns of relapse between the different subtypes of breast cancer may enable targeted adjuvant therapy and improved surveillance decisions. (C) 2012 Elsevier Ltd. All rights reserved.
语种	英语
出版者	BREAST
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93359]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wu, San-Gang,He, Zhen-Yu,Li, Qun,et al. Predictive value of breast cancer molecular subtypes in Chinese patients with four or more positive nodes after postmastectomy radiotherapy[J]. http://dx.doi.org/10.1016/j.breast.2012.07.004,2012.
APA	Wu, San-Gang.,He, Zhen-Yu.,Li, Qun.,Li, Feng-Yan.,Lin, Qin.,...&林勤.(2012).Predictive value of breast cancer molecular subtypes in Chinese patients with four or more positive nodes after postmastectomy radiotherapy.http://dx.doi.org/10.1016/j.breast.2012.07.004.
MLA	Wu, San-Gang,et al."Predictive value of breast cancer molecular subtypes in Chinese patients with four or more positive nodes after postmastectomy radiotherapy".http://dx.doi.org/10.1016/j.breast.2012.07.004 (2012).