Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System | |
Liu, Qiang ; Zhang, Juan ; Zerbinatti, Celina ; Zhan, Yan ; Kolber, Benedict J. ; Herz, Joachim ; Muglia, Louis J. ; Bu, Guojun ; Bu GJ(卜国军) | |
刊名 | http://dx.doi.org/10.1371/journal.pbio.1000575 |
2011-01 | |
关键词 | BRAIN APOLIPOPROTEIN-E ALPHA-2-MACROGLOBULIN RECEPTOR MELANOCORTIN SYSTEM GENE KNOCKOUT MOUSE-BRAIN PROTEIN EXPRESSION BALANCE MICE NEURONS |
英文摘要 | National Institutes of Health (NIH) [R01 AG02792405, P01 AG03012801, HL20948, HL63762]; Washington University DRTC [5P60DK020579]; Alzheimer's Association; Obesity is a growing epidemic characterized by excess fat storage in adipocytes. Although lipoprotein receptors play important roles in lipid uptake, their role in controlling food intake and obesity is not known. Here we show that the lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis. Conditional deletion of the Lrp1 gene in the brain resulted in an obese phenotype characterized by increased food intake, decreased energy consumption, and decreased leptin signaling. LRP1 directly binds to leptin and the leptin receptor complex and is required for leptin receptor phosphorylation and Stat3 activation. We further showed that deletion of the Lrp1 gene specifically in the hypothalamus by Cre lentivirus injection is sufficient to trigger accelerated weight gain. Together, our results demonstrate that the lipoprotein receptor LRP1, which is critical in lipid metabolism, also regulates food intake and energy homeostasis in the adult central nervous system. |
语种 | 英语 |
出版者 | PLOS BIOL |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/93273] |
专题 | 医学院-已发表论文 |
推荐引用方式 GB/T 7714 | Liu, Qiang,Zhang, Juan,Zerbinatti, Celina,et al. Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System[J]. http://dx.doi.org/10.1371/journal.pbio.1000575,2011. |
APA | Liu, Qiang.,Zhang, Juan.,Zerbinatti, Celina.,Zhan, Yan.,Kolber, Benedict J..,...&卜国军.(2011).Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System.http://dx.doi.org/10.1371/journal.pbio.1000575. |
MLA | Liu, Qiang,et al."Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System".http://dx.doi.org/10.1371/journal.pbio.1000575 (2011). |
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