Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF

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	Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF
	Yang, Lijuan ; Lin, Zhixiong ; Lin, Jianhua ; Weng, Shenmei ; Huang, Qian ; Zhang, Pengfei ; Fu, Jin ; Fu J(傅瑾)
刊名	http://dx.doi.org/10.3892/ijo.2010.871
	2011-02
关键词	TUMOR-GROWTH GENE-THERAPY ANGIOGENESIS MODEL CANCER ANGIOSTATIN METASTASIS INHIBITION
英文摘要	Science and Technology Commission, Fujian, China [02Y034]; Endostatin is an anti-angiogenic agent that blocks endothelial cell proliferation, tumor growth, and metastasis. Several lines of direct evidence show that gliomas express high levels of endostatin. However, the anti-angiogenic activity and cellular mechanisms of endostatin from tumor cells have not been completely elucidated. In this study, we established C6 glioblastoma (GBM) xenografts in nude mice by subcutaneously injecting glioma cell lines, C6-null cells, and stable transfected-C6 cells overexpressing mock vector (C6-mock) and endostatin (C6-endo). We found that overexpression of endostatin in C6-endo cells significantly suppressed the expression of VEGF in tumor cells in vivo as well as in vitro. Furthermore, the tumor growth derived from C6-endo cells was inhibited. Our data demonstrate that endostatin could play a direct role in inhibiting tumor cells, and suggest that enhancing endostatin expression in gliomas could be an effective treatment strategy.
语种	英语
出版者	INT J ONCOL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93259]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Yang, Lijuan,Lin, Zhixiong,Lin, Jianhua,et al. Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF[J]. http://dx.doi.org/10.3892/ijo.2010.871,2011.
APA	Yang, Lijuan.,Lin, Zhixiong.,Lin, Jianhua.,Weng, Shenmei.,Huang, Qian.,...&傅瑾.(2011).Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF.http://dx.doi.org/10.3892/ijo.2010.871.
MLA	Yang, Lijuan,et al."Antitumor effect of endostatin overexpressed in C6 glioma cells is associated with the down-regulation of VEGF".http://dx.doi.org/10.3892/ijo.2010.871 (2011).