Formaldehyde suppresses neuronal apoptosis via inhibition of outward K+ currents in rat hippocampus

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	Formaldehyde suppresses neuronal apoptosis via inhibition of outward K+ currents in rat hippocampus
	Liu, Pei ; Guo, Jianli ; Qi, Zhi ; Qi Z(戚智)
刊名	http://dx.doi.org/10.1139/Y11-083
	2011-09
关键词	LYMPHOHEMATOPOIETIC MALIGNANCIES INHALATION EXPOSURE GAS-CHROMATOGRAPHY FISCHER-344 RATS ACTIVATION EXPRESSION INDUSTRIES INCREASES MORTALITY WORKERS
英文摘要	National Basic Research Program of China [2005CB522804]; National Science Foundation of China [31070741]; Formaldehyde (FA) is widely present in the environment, and is also a mammalian metabolite. However, its biological role has not been well understood. Here, we show that FA plays an anti-apoptotic role in cultured hippocampal neurons: FA suppressed staurosporine-induced neuronal apoptosis and inhibited the activity of apoptosis-associated caspase-3/7 proteases in a concentration-dependent manner. Moreover, FA suppressed outward K+ currents and attenuated the enhanced I-K currents that are associated with neuronal apoptosis. As an increase in outward K+ currents is critical for cell apoptosis, our results suggest that FA exerts its anti-apoptotic effects on neuronal cells, probably through its inhibitory effect on the outward K+ currents.
语种	英语
出版者	CAN J PHYSIOL PHARM
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93245]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Liu, Pei,Guo, Jianli,Qi, Zhi,et al. Formaldehyde suppresses neuronal apoptosis via inhibition of outward K+ currents in rat hippocampus[J]. http://dx.doi.org/10.1139/Y11-083,2011.
APA	Liu, Pei,Guo, Jianli,Qi, Zhi,&戚智.(2011).Formaldehyde suppresses neuronal apoptosis via inhibition of outward K+ currents in rat hippocampus.http://dx.doi.org/10.1139/Y11-083.
MLA	Liu, Pei,et al."Formaldehyde suppresses neuronal apoptosis via inhibition of outward K+ currents in rat hippocampus".http://dx.doi.org/10.1139/Y11-083 (2011).