P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910

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	P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910
	Li, Liang-Hui ; Zheng, Min-Hua ; Luo, Qi ; Ye, Qing ; Feng, Bo ; Lu, Ai-Guo ; Wang, Ming-Liang ; Chen, Xue-Hua ; Su, Li-Ping ; Liu, Bing-Ya ; Luo Q(罗琪)
刊名	http://dx.doi.org/10.3892/ijo_00000746
	2010-10
关键词	ACTIN CYTOSKELETON CELL-MIGRATION PAK1 GROWTH REORGANIZATION CARCINOMA ORGANIZATION EXPRESSION
英文摘要	Pak1 has been reported to be overexpressed in colorectal cancer, but the role of Pak1 in colorectal cancer remains unclear. In this study, Pak1 expression and activity were associated with aggressive behavior of colorectal cancer. Overexpression of Pak1 increased colorectal cancer cell motility and invasion, whereas down-regulation of Pak1 expression or activity reduced colorectal cancer cell migration and invasion. In addition, activated Pak1 inhibited stress fiber and focal adhesion complex formation in colorectal cancer cells and led to formation of motile phenotypes. Importantly, activated Pak1 elicited phosphorylation of FAK at Ser-910 via an ERK-dependent pathway in colorectal cancer cell lines and clinical samples. In conclusion, our results suggest that activated Pak1 regulates colorectal cancer metastasis requiring an ERK-dependent phosphorylation of FAK at Ser-910.
语种	英语
出版者	INT J ONCOL
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93178]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Li, Liang-Hui,Zheng, Min-Hua,Luo, Qi,et al. P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910[J]. http://dx.doi.org/10.3892/ijo_00000746,2010.
APA	Li, Liang-Hui.,Zheng, Min-Hua.,Luo, Qi.,Ye, Qing.,Feng, Bo.,...&罗琪.(2010).P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910.http://dx.doi.org/10.3892/ijo_00000746.
MLA	Li, Liang-Hui,et al."P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910".http://dx.doi.org/10.3892/ijo_00000746 (2010).