Expression of HBx protein in hepatitis B virus-infected intrahepatic cholangiocarcinoma

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	Expression of HBx protein in hepatitis B virus-infected intrahepatic cholangiocarcinoma
	Zhou, Yan-Ming ; Cao, Lu ; Li, Bin ; Zhang, Xiu-Zhong ; Yin, Zheng-Feng ; Li B(李滨) ; Zhou YM(周彦明)
刊名	http://dx.doi.org/10.1016/S1499-3872(12)60219-7
	2012-10-15
关键词	PRIMARY SCLEROSING CHOLANGITIS HEPATOCELLULAR-CARCINOMA GENE-EXPRESSION LIVER-CIRRHOSIS RISK-FACTORS CANCER P53 CELLS
英文摘要	BACKGROUND: Hepatitis B virus (HBV) is an etiological factor of intrahepatic cholangiocarcinoma (ICC), but the pathogenic mechanisms remain unclear. This study aimed to investigate the expression and possible role of HBx, an HBV-encoded potentially oncogenic protein, in HBV-infected ICC. METHODS: Tissue samples were obtained from 54 specimens of HBV-infected ICC. Forty-four specimens were of peripheral type and 10 hilar type. Formalin-fixed, paraffin-embedded sections of the specimens were immunohistochemically stained for HBx and p53. RESULTS: HBx expression was found in 70.4% (38/54) of the specimens, and it was more frequently seen in the peripheral type than in the hilar type (79.5% vs 30.0%, P=0.002). All three well-differentiated ICCs expressed HBx, whereas 76.9% (30/39) moderately-differentiated and 41.7% (5/12) poorly-differentiated ICCs had HBx expression (P=0.033). Patients with HBx expression had a significantly higher prevalence of elevated serum alpha-fetoprotein (P=0.033). p53 protein expression was found in 18 of 54 cases (33.3%), and was not correlated with that of HBx. CONCLUSIONS: HBx may contribute to the pathogenesis of ICC, particularly the peripheral type. p53 abnormality may not play a significant role in HBx-mediated oncogenicity during ICC carcinogenesis. (Hepatobiliary Pancreat Dis Int 2012;11:532-535)
语种	英语
出版者	HEPATOB PANCREAT DIS
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93106]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhou, Yan-Ming,Cao, Lu,Li, Bin,et al. Expression of HBx protein in hepatitis B virus-infected intrahepatic cholangiocarcinoma[J]. http://dx.doi.org/10.1016/S1499-3872(12)60219-7,2012.
APA	Zhou, Yan-Ming.,Cao, Lu.,Li, Bin.,Zhang, Xiu-Zhong.,Yin, Zheng-Feng.,...&周彦明.(2012).Expression of HBx protein in hepatitis B virus-infected intrahepatic cholangiocarcinoma.http://dx.doi.org/10.1016/S1499-3872(12)60219-7.
MLA	Zhou, Yan-Ming,et al."Expression of HBx protein in hepatitis B virus-infected intrahepatic cholangiocarcinoma".http://dx.doi.org/10.1016/S1499-3872(12)60219-7 (2012).