Fabrication of core-shell microspheres using alginate and chitosan-polycaprolactone for controlled release of vascular endothelial growth factor

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	Fabrication of core-shell microspheres using alginate and chitosan-polycaprolactone for controlled release of vascular endothelial growth factor
	Wu, Hua ; Liao, Chunyan ; Jiao, Qianyi ; Wang, Zheng ; Cheng, Wenze ; Wan, Ying ; Wu H(吴华)
刊名	http://dx.doi.org/10.1016/j.reactfunctpolym.2012.04.007
	2012-07
关键词	PROTEIN DELIVERY DRUG-RELEASE IN-VITRO CROSS-LINKING BEADS ANGIOGENESIS PERSPECTIVES MEMBRANES HYDROGELS GENIPIN
英文摘要	National Natural Science Foundation of China [81071470]; Alginate microspheres loaded with vascular endothelial growth factor (VEGF) were prepared via an emulsification method using calcium chloride as a crosslinker. The microspheres with encapsulation efficiency of about 80% were coated by chitosan-polycaprolactone (CH-PCL) with various PCL percentages changing from around 15 to 42 wt.% to fabricate core-shell alginate/CH-PCL microspheres with an average size of around 40 pm. It was found that the CH-PCL coating layer on the core-shell microspheres could have a sandwich-like structure. The PCL content in the CH-PCLs and the concentration of CH-PCL solutions in preparing the microsphere functioned as two key factors to regulate the release profiles of the microspheres. Some selected alginate/CH-PCL microspheres were further crosslinked using genipin as a crosslinker, and the amount of genipin was found to be another impactful factor to mediate the release patterns of the microspheres. In vitro release measurements revealed that VEGF-release from these core-shell microspheres was controlled either by Fickian diffusion or non-Fickian transport that involves both diffusion and swelling. Some optimized core-shell microspheres were capable of maintaining sustained VEGF-release in an approximately linear manner over a period of time longer than 4 weeks and did not involve a significant initial burst. (C) 2012 Elsevier Ltd. All rights reserved.
语种	英语
出版者	REACT FUNCT POLYM
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93086]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wu, Hua,Liao, Chunyan,Jiao, Qianyi,et al. Fabrication of core-shell microspheres using alginate and chitosan-polycaprolactone for controlled release of vascular endothelial growth factor[J]. http://dx.doi.org/10.1016/j.reactfunctpolym.2012.04.007,2012.
APA	Wu, Hua.,Liao, Chunyan.,Jiao, Qianyi.,Wang, Zheng.,Cheng, Wenze.,...&吴华.(2012).Fabrication of core-shell microspheres using alginate and chitosan-polycaprolactone for controlled release of vascular endothelial growth factor.http://dx.doi.org/10.1016/j.reactfunctpolym.2012.04.007.
MLA	Wu, Hua,et al."Fabrication of core-shell microspheres using alginate and chitosan-polycaprolactone for controlled release of vascular endothelial growth factor".http://dx.doi.org/10.1016/j.reactfunctpolym.2012.04.007 (2012).