| Immunosuppressive effect of compound K on islet transplantation in a STZ-induced diabetic mouse model | |
| Peng-Fei Ma ; Ma PF(马鹏飞) ; Jie Jiang ; Jiang J(姜杰) ; Chang Gao ; Pan-Pan Cheng ; Jia-Li Li ; Xin Huang ; Ying-Ying Lin ; Qing Li ; Yuan-Zheng Peng ; Peng YZ(彭园征) ; Mei-Chun Cai ; Wei Shao ; Shao W(邵巍) ; Qi Zhu ; Sai Han ; Qing Qin ; Jun-Jie Xia ; Xia JJ(夏俊杰) ; Zhong-Quan Qi ; Qi ZQ(齐忠权) | |
| 2014-05-16 | |
| 英文摘要 | 齐忠权，厦门大学医学院副院长、厦门大学器官移植研究所所长。; Islet transplantation is a therapeutic option for type 1 diabetes, but its long-term success is limited by islet allograft survival. Many factors imperil islet survival, especially the adverse effects and toxicity due to clinical immunosuppressants. Compound (Cpd) K is a synthesized analog of highly unsaturated fatty acids from Isatis tinctoria L. (Cruciferae). Here we investigated the therapeutic effect of Cpd K in diabetic mice and found that it significantly prolonged islet allograft survival with minimal adverse effects after 10 days. Furthermore, it reduced the proportion of CD4(+) and CD8(+) T cells in spleen and lymph nodes, inhibited inflammatory cell infiltration in allografts, suppressed serum interleukin-2 and interferon-γ secretion, and increased transforming growth factor-β and Foxp3 mRNA expression. Surprisingly, Cpd K and rapamycin had a synergistic effect. Cpd K suppressed proliferation of naïve T cells by inducing T-cell anergy and promoting the generation of regulatory T cells. In addition, nuclear factor-κB signaling was also blocked. Taken together, these findings indicate that Cpd K may have a potential immunosuppressant effect on islet transplantation. © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.; 该项研究工作得到了国家科技部（973课题）、国家自然科学基金委等的经费支持。 |
| 语种 | 英语 |
| 出版者 | American Diabetes Association |
| 内容类型 | 期刊论文 |
| 源URL | [http://dx.doi.org/10.2337/db14-0012]  |
| 专题 | 医学院－已发表论文 |
| 推荐引用方式 GB/T 7714 | Peng-Fei Ma,Ma PF,Jie Jiang,et al. Immunosuppressive effect of compound K on islet transplantation in a STZ-induced diabetic mouse model[J],2014. |
| APA | Peng-Fei Ma.,马鹏飞.,Jie Jiang.,姜杰.,Chang Gao.,...&齐忠权.(2014).Immunosuppressive effect of compound K on islet transplantation in a STZ-induced diabetic mouse model.. |
| MLA | Peng-Fei Ma,et al."Immunosuppressive effect of compound K on islet transplantation in a STZ-induced diabetic mouse model".(2014). |
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