Molecular modeling of zinc and copper binding with Alzheimer's amyloid beta-peptide

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	Molecular modeling of zinc and copper binding with Alzheimer's amyloid beta-peptide
	Han, D. X. ; Wang, H. Y. ; Yang, P. ; Han DX(韩大雄)
刊名	http://dx.doi.org/10.1007/s10534-007-9107-6
	2008-04
关键词	METAL-BINDING A-BETA PRECURSOR PROTEIN FORCE-FIELD IN-VITRO DISEASE AGGREGATION MORPHOLOGY MECHANISM MODES
英文摘要	Aggregation of the amyloid beta-peptide (A beta) into insoluble fibrils is a key pathological event in Alzheimer's disease. Cu(II) and Zn(II) ions were reported to be able to induce A beta aggregation at nearly physiological concentrations in vitro. In this study, the binding modes of Cu(II) and Zn(II) in this process were explored by molecular modeling. In the pre-associated A beta, N tau atom of imidazole ring of His14, O atom of carbonyl of main-chain and two O atoms of water occupied the four ligand positions of the complex. While in the aggregated form of A beta, the His13(N)-Metals-His14(N) bridges were formed through metal cross-linking action. These results would be helpful to put insight on revealing the formation mechanism of pathogenic A beta aggregates in brain.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/71511]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Han, D. X.,Wang, H. Y.,Yang, P.,et al. Molecular modeling of zinc and copper binding with Alzheimer's amyloid beta-peptide[J]. http://dx.doi.org/10.1007/s10534-007-9107-6,2008.
APA	Han, D. X.,Wang, H. Y.,Yang, P.,&韩大雄.(2008).Molecular modeling of zinc and copper binding with Alzheimer's amyloid beta-peptide.http://dx.doi.org/10.1007/s10534-007-9107-6.
MLA	Han, D. X.,et al."Molecular modeling of zinc and copper binding with Alzheimer's amyloid beta-peptide".http://dx.doi.org/10.1007/s10534-007-9107-6 (2008).