Molecular modeling of zinc and copper binding with Alzheimer‘s amyloid beta-peptide | |
Han, Daxiong ; Wang, Haiyan ; Yang, Pin ; Han DX(韩大雄) | |
刊名 | http://dx.doi.org/10.1007/s10534-007-9107-6
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2008-04 | |
关键词 | METAL-BINDING A-BETA PRECURSOR PROTEIN FORCE-FIELD IN-VITRO DISEASE AGGREGATION MORPHOLOGY MECHANISM MODES |
英文摘要 | Aggregation of the amyloid beta-peptide (A beta) into insoluble fibrils is a key pathological event in Alzheimer's disease. Cu(II) and Zn(II) ions were reported to be able to induce A beta aggregation at nearly physiological concentrations in vitro. In this study, the binding modes of Cu(II) and Zn(II) in this process were explored by molecular modeling. In the pre-associated A beta, N tau atom of imidazole ring of His14, O atom of carbonyl of main-chain and two O atoms of water occupied the four ligand positions of the complex. While in the aggregated form of A beta, the His13(N)-Metals-His14(N) bridges were formed through metal cross-linking action. These results would be helpful to put insight on revealing the formation mechanism of pathogenic A beta aggregates in brain. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/71510] ![]() |
专题 | 医学院-已发表论文 |
推荐引用方式 GB/T 7714 | Han, Daxiong,Wang, Haiyan,Yang, Pin,et al. Molecular modeling of zinc and copper binding with Alzheimer‘s amyloid beta-peptide[J]. http://dx.doi.org/10.1007/s10534-007-9107-6,2008. |
APA | Han, Daxiong,Wang, Haiyan,Yang, Pin,&韩大雄.(2008).Molecular modeling of zinc and copper binding with Alzheimer‘s amyloid beta-peptide.http://dx.doi.org/10.1007/s10534-007-9107-6. |
MLA | Han, Daxiong,et al."Molecular modeling of zinc and copper binding with Alzheimer‘s amyloid beta-peptide".http://dx.doi.org/10.1007/s10534-007-9107-6 (2008). |
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