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	Synthesis of a novel galactosylated lipid and its application to the hepatocyte-selective targeting of liposomal doxorubicin
	Wang, S. N. ; Deng, Y. H. ; Xu, H. ; Wu, H. B. ; Qiu, Y. K. ; Chen, D. W. ; Qiu YK(邱鹰昆)
	2006
关键词	galactosytated lipid hepatocyte-selective targeting parenchymal cells liposomes doxorubicin
英文摘要	This paper described the synthesis of a novel galactosylated lipid with mono-galactoside moiety, (5-Cholesten-3 beta-yl) 4-oxo-4-[2-(lactobionyl amido) ethylamido] butanoate (CHS-ED-LA), and the targetability of doxorubicin (DOX). a model drug, in liposomes containing 10% mol/mol CHS-ED-LA (galactosylated liposomes, GaIL) to the liver was Studied. The weighted-average overall drug targeting efficiency (Te*) was used to evaluate the liver targetability of GaIL DOX. The results showed that GaIL DOX gave a relatively high (Te*)(liver) value of 64.6%, while DOX in conventional liposome (CL DOX) only gave a (Te*)liver value of 21.8%. In the liver, the GaIL DOX was mainly taken up by parenchymal cells (88% of the total hepatic uptake). Moreover, preinjection of asialofetuin significantly inhibited the liver uptake of GaIL DOX (from 70 to 12% of the total injected dose). It was suggested that liposomes containing such novel galactosylated lipid, CHS-ED-LA, had a great potential as drug delivery carriers for hepatocyte-selective targeting. (c) 2005 Elsevier B.V. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/71497]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wang, S. N.,Deng, Y. H.,Xu, H.,et al. Synthesis of a novel galactosylated lipid and its application to the hepatocyte-selective targeting of liposomal doxorubicin[J],2006.
APA	Wang, S. N..,Deng, Y. H..,Xu, H..,Wu, H. B..,Qiu, Y. K..,...&邱鹰昆.(2006).Synthesis of a novel galactosylated lipid and its application to the hepatocyte-selective targeting of liposomal doxorubicin..
MLA	Wang, S. N.,et al."Synthesis of a novel galactosylated lipid and its application to the hepatocyte-selective targeting of liposomal doxorubicin".(2006).

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