Preparation and characterization of self-aggregated nanoparticles of cholesterol-modified O-carboxymethyl chitosan conjugates

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	Preparation and characterization of self-aggregated nanoparticles of cholesterol-modified O-carboxymethyl chitosan conjugates
	Wang, Y. S. ; Liu, L. R. ; Weng, J. ; Zhang, Q. Q. ; Zhang QQ(张其清)
刊名	http://dx.doi.org/10.1016/j.carbpol.2007.01.016
	2007-06-25
关键词	ACID-MODIFIED CHITOSAN HYDROGEL NANOPARTICLE HYDROPHOBIZED POLYSACCHARIDE ASSEMBLED NANOPARTICLES ALKYLATED CHITOSAN POLYMERIC VESICLES GENE TRANSFECTION MOLECULAR-WEIGHT AQUEOUS-SOLUTION BILE-ACIDS
英文摘要	A series of cholesterol-modified O-carboxymethyl chitosan (CCMC) conjugates with different degrees of substitution (DS) of cholesterol moiety were synthesized by the succinyl linkages and characterized by Fourier transform infrared (FTIR), proton nuclear magnetic resonance (H-1 NMR) and elemental analysis. CCMC conjugates were amphiphilic in nature and their self-aggregation behavior in aqueous media was evaluated by the fluorescence probe technique. CCMC self-aggregated nanoparticles were prepared by probe sonication in water and analyzed by dynamic laser light-scattering (DLLS), zeta potential and transmission electron microscopy (TEM) technologies. These novel nanoparticles were almost spherical in shape, and their size, ranging from 234.9 to 100. 1 nm, could be controlled by DS of cholesterol moiety. The zeta potentials of CCMC self-aggregated nanoparticles were negative, and the absolute values decreased with increasing DS of the cholesterol moiety. This study also compared the morphology and the stability of self-aggregated nanoparticles between CCMC and cholesterol-modified chitosan (CHCS). The results showed that the negatively charged carboxymethyl groups are advantageous for the formation of well-shaped and stable self-aggregated nanoparticles. (C) 2007 Published by Elsevier Ltd.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/71465]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wang, Y. S.,Liu, L. R.,Weng, J.,et al. Preparation and characterization of self-aggregated nanoparticles of cholesterol-modified O-carboxymethyl chitosan conjugates[J]. http://dx.doi.org/10.1016/j.carbpol.2007.01.016,2007.
APA	Wang, Y. S.,Liu, L. R.,Weng, J.,Zhang, Q. Q.,&张其清.(2007).Preparation and characterization of self-aggregated nanoparticles of cholesterol-modified O-carboxymethyl chitosan conjugates.http://dx.doi.org/10.1016/j.carbpol.2007.01.016.
MLA	Wang, Y. S.,et al."Preparation and characterization of self-aggregated nanoparticles of cholesterol-modified O-carboxymethyl chitosan conjugates".http://dx.doi.org/10.1016/j.carbpol.2007.01.016 (2007).