Pullulan acetate nanoparticles prepared by solvent diffusion method for epirubicin chemotherapy

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	Pullulan acetate nanoparticles prepared by solvent diffusion method for epirubicin chemotherapy
	Zhang, H. Z. ; Gao, F. P. ; Liu, L. R. ; Li, M. M. ; Zhou, Z. M. ; Yang, X. D. ; Zhang, Q. Q. ; Zhang QQ(张其清)
刊名	http://dx.doi.org/10.1016/j.colsurfb.2008.12.039
	2009-06-01
关键词	CHOLESTEROL-BEARING PULLULAN POLYSACCHARIDE COMPLEXATION NANOSPHERES POLYMERS
英文摘要	Major State Basic Research Program of China [2006 CB 933300]; Doctoral Fund of Ministry of Education of China [20060023050]; Pullulan acetate (PA) was synthesized by the reaction of pullulan with acetic anhydride in the presence of pyridine. PA was characterized by Fourier transform infrared (FT-IR) and proton nuclear magnetic resonance ((1)H NMR). A solvent diffusion method was employed in the current work to prepare PA nanoparticles. This technique had some advantages compared with other methods. The article size increased from 185.7 nm to 423.0 nm with the degree of acetylation increasing from 2.71 to 3.0. Drug-loaded PA nanopaticles were prepared for controlled release of epirubicin (EPI). The drug entrapment and drug content increased with the degree substitution of PA increasing. EPI was released from the nanoparticles in a biphasic profile with a fast release rate in the first 10h followed by a slow release in vitro. A higher cytotoxicity against KB cells was found for EPI-loaded PA nanoparticles in comparison with free EPI. Confocal laser scanning microscopy (CLSM) observations indicate that EPI-loaded nanoparticles were internalized and released in the cytoplasmic compartment. (C) 2009 Elsevier B.V. All rights reserved
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/71443]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Zhang, H. Z.,Gao, F. P.,Liu, L. R.,et al. Pullulan acetate nanoparticles prepared by solvent diffusion method for epirubicin chemotherapy[J]. http://dx.doi.org/10.1016/j.colsurfb.2008.12.039,2009.
APA	Zhang, H. Z..,Gao, F. P..,Liu, L. R..,Li, M. M..,Zhou, Z. M..,...&张其清.(2009).Pullulan acetate nanoparticles prepared by solvent diffusion method for epirubicin chemotherapy.http://dx.doi.org/10.1016/j.colsurfb.2008.12.039.
MLA	Zhang, H. Z.,et al."Pullulan acetate nanoparticles prepared by solvent diffusion method for epirubicin chemotherapy".http://dx.doi.org/10.1016/j.colsurfb.2008.12.039 (2009).