Self-aggregated nanoparticles of cholesterol-modified chitosan conjugate as a novel carrier of epirubicin

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	Self-aggregated nanoparticles of cholesterol-modified chitosan conjugate as a novel carrier of epirubicin
	Wang, Y. S. ; Liu, L. R. ; Jiang, Q. ; Zhang, Q. Q. ; Zhang QQ(张其清)
刊名	http://dx.doi.org/10.1016/j.eurpolymj.2006.09.007
	2007-01
关键词	ACID-MODIFIED CHITOSAN HYDROPHOBICALLY-MODIFIED CHITOSANS CRITICAL MICELLE CONCENTRATION COLLOIDAL DRUG CARRIERS ASSEMBLED NANOPARTICLES HYDROGEL NANOPARTICLE ALKYLATED CHITOSAN POLYMERIC VESICLES FLUORESCENCE DELIVERY
英文摘要	Cholesterol-modified chitosan conjugate with succinyl linkages (CHCS) was synthesized and characterized by fourier transform infrared (FTIR) and,proton nuclear magnetic resonance (H-1 NMR). The degree of substitution (DS) of cholesterol moiety determined by elemental analysis was 7.3%. The self-aggregation behavior of CHCS was evaluated by the fluorescence probe technique and the critical aggregation concentration (CAC) was 1.16 x 10(-2) mg mL(-1) in 0.1 M acetic acid solution. CHCS formed monodisperse self-aggregated nanoparticles with a roughly spherical shape and a mean diameter of 417.2 nm by probe sonication in aqueous media. Epirubicin (EPB), as a model anticancer drug, was physically entrapped inside CHCS self-aggregated nanoparticles by the remote loading method and the characteristics of EPB-loaded CHCS self-aggregated nanoparticles were analyzed using dynamic laser light scattering (DLLS), transmission electron microscopy (TEM) and fluorescence spectroscopy. EPB-loaded CHCS self-aggregated nanoparticles were almost spherical in shape and their size increased from 338.2 to 472.9 nm with the EPB-loading content increasing from 7.97% to 14.0%. The release behavior of EPB from CHCS self-aggregated nanoparticles was studied in vitro by dialysis method. The results showed that EPB release rate decreased with the pH increase of the release media. In phosphate buffered saline (PBS, pH 7.4), the EPB release was very slow and the total release amount was about 24.9% in 48 h. (c) 2006 Published by Elsevier Ltd.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/71440]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Wang, Y. S.,Liu, L. R.,Jiang, Q.,et al. Self-aggregated nanoparticles of cholesterol-modified chitosan conjugate as a novel carrier of epirubicin[J]. http://dx.doi.org/10.1016/j.eurpolymj.2006.09.007,2007.
APA	Wang, Y. S.,Liu, L. R.,Jiang, Q.,Zhang, Q. Q.,&张其清.(2007).Self-aggregated nanoparticles of cholesterol-modified chitosan conjugate as a novel carrier of epirubicin.http://dx.doi.org/10.1016/j.eurpolymj.2006.09.007.
MLA	Wang, Y. S.,et al."Self-aggregated nanoparticles of cholesterol-modified chitosan conjugate as a novel carrier of epirubicin".http://dx.doi.org/10.1016/j.eurpolymj.2006.09.007 (2007).