Potential wound dressing with improved antimicrobial property | |
Guan, M. ; Ren, L. ; Wu, T. ; Sun, L. P. ; Li, L. R. ; Zhang, Q. Q. ; Zhang QQ(张其清) | |
刊名 | http://dx.doi.org/10.1002/app.26291
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2007-08-05 | |
关键词 | COLLAGEN CHITOSAN SILVER SCAFFOLDS MATRICES CULTURE |
英文摘要 | Cultured skin substitutes have provided a new approach for the closure of wounds, but these avascular grafts are subject to microbial destruction that may lead to tissue infection. To minimize wound infection, HN-300 (a new inorganic antimicrobial particle) was incorporated into the collagen-chitosan wound dressing. Antimicrobial, cytotoxicity, release rate, swelling, and mechanical properties of this material were assessed. The antimicrobial property was enhanced with the increasing dosage of HN-300. When the concentration of HN-300 was more than 5%, the films showed sustained and stable anti microbial property within 144 h. When the concentration of HN-300 was less than 7.5'%, the wound dressings were noncytotoxic and compatible for L929 fibroblasts. So 5%, HN-300 in antimicrobial films was suitable and the concentration also could improve the mechanical properties of the collagen-chitosan wound dressings. After treatment with 5% glycerol, the film's stability was enhanced and silver ions were protected at the same time. Hence, collagen/chitosan/HN-300 films are of great potential in application as wound dressing in future, because of their good biosafety and physical properties. (c) 2007 Wiley Periodicals, Inc. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://dspace.xmu.edu.cn/handle/2288/71437] ![]() |
专题 | 医学院-已发表论文 |
推荐引用方式 GB/T 7714 | Guan, M.,Ren, L.,Wu, T.,et al. Potential wound dressing with improved antimicrobial property[J]. http://dx.doi.org/10.1002/app.26291,2007. |
APA | Guan, M..,Ren, L..,Wu, T..,Sun, L. P..,Li, L. R..,...&张其清.(2007).Potential wound dressing with improved antimicrobial property.http://dx.doi.org/10.1002/app.26291. |
MLA | Guan, M.,et al."Potential wound dressing with improved antimicrobial property".http://dx.doi.org/10.1002/app.26291 (2007). |
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