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	Preparation and Characterization of PLGA Nanospheres Surface Modified with Biotinylated Chitosan
	Chen, H. L. ; Tang, H. B. ; Yang, W. Z. ; Chen, H. ; Wang, Y. S. ; Mei, L. ; Zhang, T. ; Xiong, Q. Q. ; Zhang, Q. Q. ; Zhang QQ(张其清)
	2010
关键词	Nanoparticle Poly(lactic-co-glycolic acid) (PLGA) Biotinylated chitosan anticancer
英文摘要	Biotinylated chitosan (Bio-CS conjugates or Bio-CS) were synthesized and characterized. The degree of substitution(DS), as defined as the number of biotin per 100 anhydroglucose units of CS, was determined by (1)H NMR and ICP. Poly (lactic-co-glycolic acid) (PLGA) nanospheres were prepared by a solvent evaporation technique(W(1)/O/W(2)). The surface of PLGA nanosphere was modified with Bio-CS by covalent binding. PLGA nanospheres were almost spherical in shape under the scanning electron microscopy (SEM) observation, and their mean diameter determined by the laser light scattering technique was (248.4 +/- 21.0) urn. Bio-CS modified PLGA nanospheres were also spherical in shape; their mean diameter and Zeta potential value were (268.3 +/- 23.4) nm and (21.21 +/- 2.13) mV, respectively. The surface chemistry of nanospheres was quantitatively studied by X-ray photoelectron spectroscopy(XPS). The results show the N region corresponding to the primary amide of CS and the S region corresponding to the biotin, indicating that PLGA nanospheres were successfully surface-modified with Bio-CS. The content of biotin on the surface of Bio-CS modified PLGA nanospheres with DS of biotin of 31% was determined using a commercially available Quant * Tag (TM) Biotin Kit and its value was (1.36 +/- 0.34) mol/100 mg.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/71432]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Chen, H. L.,Tang, H. B.,Yang, W. Z.,et al. Preparation and Characterization of PLGA Nanospheres Surface Modified with Biotinylated Chitosan[J],2010.
APA	Chen, H. L..,Tang, H. B..,Yang, W. Z..,Chen, H..,Wang, Y. S..,...&张其清.(2010).Preparation and Characterization of PLGA Nanospheres Surface Modified with Biotinylated Chitosan..
MLA	Chen, H. L.,et al."Preparation and Characterization of PLGA Nanospheres Surface Modified with Biotinylated Chitosan".(2010).

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