Formation of poly(L,D-lactide) spheres with controlled size by direct dialysis

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	Formation of poly(L,D-lactide) spheres with controlled size by direct dialysis
	Liu, M. ; Zhou, Z. M. ; Wang, X. F. ; Xu, J. ; Yang, K. ; Cui, Q. ; Chen, X. ; Cao, M. Y. ; Weng, J. ; Zhang, Q. Q. ; Zhang QQ(张其清)
刊名	http://dx.doi.org/10.1016/j.polymer.2007.07.053
	2007-09-10
关键词	POLY(DL-LACTIDE-CO-GLYCOLIDE) NANOPARTICLES CONTROLLED-RELEASE PARTICLE-SIZE IN-VITRO MICROSPHERES DELIVERY SURFACTANT CARRIERS POLYMER ACID)
英文摘要	In this work, we show that simple dialysis of a poly(DL-lactic acid) (PLA) solution against water resulted in the spontaneous formation of PLA spheres. We observed initial formation of particles with irregular shape and large size, which then were disrupted into uniform and smooth nanospheres. Further, the formation process of PLA spheres was also investigated by dynamic light scattering technique (DLS) in situ. Based on these experimental results, it was proposed that the PLA spheres were formed in three steps: (1) aggregation - individual PLA chains got aggregated with each other in solution; (2) formation and disruption of PLA particles; (3) solidification of PLA spheres. In addition, the size of the spheres could be well controlled by the preparation conditions such as the speed of dialysis, initial solvent, initial water content and polymer concentration. The ease with which these spheres could be fabricated and the ability to control the size of spheres should facilitate investigations of their scope for drug delivery. (C) 2007 Elsevier Ltd. All rights reserved.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/71389]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Liu, M.,Zhou, Z. M.,Wang, X. F.,et al. Formation of poly(L,D-lactide) spheres with controlled size by direct dialysis[J]. http://dx.doi.org/10.1016/j.polymer.2007.07.053,2007.
APA	Liu, M..,Zhou, Z. M..,Wang, X. F..,Xu, J..,Yang, K..,...&张其清.(2007).Formation of poly(L,D-lactide) spheres with controlled size by direct dialysis.http://dx.doi.org/10.1016/j.polymer.2007.07.053.
MLA	Liu, M.,et al."Formation of poly(L,D-lactide) spheres with controlled size by direct dialysis".http://dx.doi.org/10.1016/j.polymer.2007.07.053 (2007).