In vivo imaging and drug storage by quantum-dot-conjugated carbon nanotubes

CORC > 厦门大学 > 医学院－已发表论文

	In vivo imaging and drug storage by quantum-dot-conjugated carbon nanotubes
	Guo, Y. ; Shi, D. L. ; Cho, H. S. ; Dong, Z. Y. ; Kulkarni, A. ; Pauletti, G. M. ; Wang, W. ; Lian, J. ; Liu, W. ; Ren, L. ; Zhang, Q. Q. ; Liu, G. K. ; Huth, C. ; Wang, L. M. ; Ewing, R. C. ; Zhang QQ(张其清)
刊名	http://dx.doi.org/10.1002/adfm.200800406
	2008-09-10
关键词	ULTRATHIN POLYMER-FILMS SEMICONDUCTOR NANOCRYSTALS AL2O3 NANOPARTICLES FLUORESCENCE DELIVERY CYTOTOXICITY PACLITAXEL DEPOSITION CHEMISTRY FULLERENE
英文摘要	UC Institute for Nanoscale Science and Technology; U.S. Department of Energy [W-31-109-ENG-38]; NSF NIRT [EAR-0403732]; A specially designed carbon nanotube (CNT) is developed for use in the early detection and treatment of cancer. The key functionalities for biomedical diagnosis and drug delivery are incorporated into the CNTs. In vivo imaging of live mice is achieved by intravenously injecting quantum dot (QD)-conjugated CNT for the first time. With near infrared emission around 752 nm, the CNT with surface-conjugated QD (CNT-QD) exhibit a strong luminescence for non-invasive optical in vivo imaging. CNT surface modification is achieved by a plasma polymerization approach that deposited ultra-thin acrylic acid or poly(lactic-co-glycolic acid) (PLGA) films (similar to 3 nm) onto the nanotubes. The anticancer agent paclitaxel is loaded at 11.2 +/- 5.8 mu g mg(-1) to PLGA-coated CNT. Cytotoxicity of this novel drug delivery system is evaluated in vitro using PC-3MM2 human prostate carcinoma cells and quantified by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The in vivo distribution determined by inductively coupled plasma mass spectrometry (ICP-MS) indicates CNT-QD uptake in various organs of live animals.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/71374]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Guo, Y.,Shi, D. L.,Cho, H. S.,et al. In vivo imaging and drug storage by quantum-dot-conjugated carbon nanotubes[J]. http://dx.doi.org/10.1002/adfm.200800406,2008.
APA	Guo, Y..,Shi, D. L..,Cho, H. S..,Dong, Z. Y..,Kulkarni, A..,...&张其清.(2008).In vivo imaging and drug storage by quantum-dot-conjugated carbon nanotubes.http://dx.doi.org/10.1002/adfm.200800406.
MLA	Guo, Y.,et al."In vivo imaging and drug storage by quantum-dot-conjugated carbon nanotubes".http://dx.doi.org/10.1002/adfm.200800406 (2008).