Gold-cluster sensors formed electrochemically at boron-doped-diamond electrodes: Detection of dopamine in the presence of ascorbic acid and thiols

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	Gold-cluster sensors formed electrochemically at boron-doped-diamond electrodes: Detection of dopamine in the presence of ascorbic acid and thiols
	Weng, J. ; Xue, J. M. ; Wang, J. ; Ye, J. S. ; Cui, H. F. ; Sheu, F. S. ; Zhang, Q. Q. ; Zhang QQ(张其清)
刊名	http://dx.doi.org/10.1002/adfm.200400049
	2005-04
关键词	SELF-ASSEMBLED MONOLAYERS FLOW-INJECTION ANALYSIS THIN-FILM ELECTRODES SELECTIVE DETECTION NANOPARTICLE ARRAYS CARBON-FIBER SURFACES ELECTROANALYSIS MICROELECTRODES BEHAVIOR
英文摘要	Gold clusters have been electrodeposited on a boron-doped diamond (131313) electrode by scanning the potential from 0.7 V to 0.0 V (vs. 3 M KCl-Ag/AgCl reference) in a solution of 0.5 mM KAuCl4 and 1.0 M KCl. The cluster-modified diamond (An/BDD) electrode has been used to investigate the oxidative properties of dopamine (DA) and ascorbate (AA). The modified diamond electrode shows a higher activity for DA oxidation than AA; the oxidation potential of DA shifted to a less-positive potential (0.11 V) than that of AA, which oxidized at 0.26 V, and DA possesses a much higher peak current than that of AA. The reversibility of the electrode reaction with DA is significantly improved at the Au/BDD electrode, which results in a large increase in the square-wave voltammetric peak current, with a detection limit of 0.1 mu M in the presence of a large excess of AA. The Au/BDD electrode shows excellent sensitivity and good selectivity for DA detection. A self-assembled monolayer (SAM) of mercaptoacetic acid on the Au clusters was used to provide an antifouling effect as the negative CO2- groups repulse negative ascorbate and attract positive dopamine in pH7.4 buffer. After pre-absorption, the SAM/Au/BDD electrode could detect 1.0 nM DA in a linear range from 10 nM to 10 mu M in the presence of 10(-4) M AA.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/71370]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Weng, J.,Xue, J. M.,Wang, J.,et al. Gold-cluster sensors formed electrochemically at boron-doped-diamond electrodes: Detection of dopamine in the presence of ascorbic acid and thiols[J]. http://dx.doi.org/10.1002/adfm.200400049,2005.
APA	Weng, J..,Xue, J. M..,Wang, J..,Ye, J. S..,Cui, H. F..,...&张其清.(2005).Gold-cluster sensors formed electrochemically at boron-doped-diamond electrodes: Detection of dopamine in the presence of ascorbic acid and thiols.http://dx.doi.org/10.1002/adfm.200400049.
MLA	Weng, J.,et al."Gold-cluster sensors formed electrochemically at boron-doped-diamond electrodes: Detection of dopamine in the presence of ascorbic acid and thiols".http://dx.doi.org/10.1002/adfm.200400049 (2005).