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	Novel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targeting
	Chen, Xiaoli ; Chen XL(陈晓莉) ; Lv, Haiyan ; Ye, Min ; Wang, Shengyu ; Ni, Erru ; Zeng, Fanwei ; Cao, Chang ; Luo, Fanghong ; Yan, Jianghua
	2012-04-15
关键词	Magnetic nanoparticles Superparamagnetic o-Carboxymethylchitosan Truncated tissue factor Tumor targeting
英文摘要	The goal of this study was to develop novel embolic nanoparticles for targeted tumor therapy with dual targeting: magnetic field-guided and peptide-directed targeting. The embolic nanoparticles SP5.2/tTF-OCMCs-SPIO-NPs were prepared by surface-modifying of superparamagnetic iron oxide nanoparticles (SPIO-NPs) with o-carboxymethylchitosans (OCMCs) and SP5.2/tTF (SP5.2: a peptide binding to VEGFR-1; tTF: truncated tissue factor) to improve their stability and to target over-expressing VEGFR-1 cells. The physicochemical characterization results showed that the OCMCs-SPIO-NPs have a spherical or ellipsoidal morphology with an average diameter of 10-20 nm. And they possess magnetism with a saturation magnetization of 66.1 emu/g, negligible coercivity and remanence at room temperature. In addition, the confocal microscopy, Prussian blue staining and FX activation analysis respectively demonstrated the peptide-directed targeting, magnetic field-guided targeted and blood coagulation activity of the SP5.2/tTF-OCMCs-SPIO-NPs. These properties separately belong to SP5.2, Fe3O4 and tTF moieties of the SP5.2/tTF-OCMCs-SPIO-NPs. Thus these SP5.2/tTF-OCMCs-SPIO-NPs with double-targeting function should have a potential application in embolization therapy of tumor blood vessels. (C) 2012 Elsevier B. V. All rights reserved.; National Natural Science Foundation of China [30973485, 81172970]
语种	英语
出版者	ELSEVIER SCIENCE BV
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1016/j.ijpharm.2012.01.043]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Chen, Xiaoli,Chen XL,Lv, Haiyan,et al. Novel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targeting[J],2012.
APA	Chen, Xiaoli.,陈晓莉.,Lv, Haiyan.,Ye, Min.,Wang, Shengyu.,...&Yan, Jianghua.(2012).Novel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targeting..
MLA	Chen, Xiaoli,et al."Novel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targeting".(2012).

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