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	RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility
	Poon, Kar Lai ; Tan, Kar Tong ; Wei, Yang Ye ; Ng, Chee Peng ; Colman, Alan ; Korzh, Vladimir ; Xu, Xiu Qin ; Xu XQ(许秀琴)
	2012-06
关键词	RNA-binding protein Sarcomere Cardiomyopathy Stem cells Zebrafish
英文摘要	The factors responsible for cardiomyopathy are not fully understood. Our studies of the transcriptome of human embryonic stem cell-derived cardiomyocytes identified novel genes up-regulated during cardiac differentiation, including RBM24. We therefore studied how its deficiency affected heart development. The expression of Rbm24 was detected in mouse cardiomyocytes and embryonic myocardium of zebrafish at the RNA and protein level. The Rbm24 loss-of-function showed that Rbm24 deficiency resulted in a reduction in sarcomeric proteins, Z-disc abnormality, and diminished heart contractility, resulting in the absence of circulation in zebrafish embryos. Gene expression profiling revealed down-regulation of multiple pathways associated with sarcomere assembly and vasculature development in Rbm24 deficiency. We identified a novel role of the tissue-specific RNA-binding protein (RBP) Rbm24 involving in the regulation of cardiac gene expression, sarcomeric assembly, and cardiac contractility. This study uncovers a potential novel pathway to cardiomyopathy through down-regulation of the RBP Rbm24.; Agency for Science, Technology and Research (A*STAR) of Singapore; Fundamental Research Funds for the Central Universities of China
语种	英语
出版者	OXFORD UNIV PRESS
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1093/cvr/cvs095]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Poon, Kar Lai,Tan, Kar Tong,Wei, Yang Ye,et al. RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility[J],2012.
APA	Poon, Kar Lai.,Tan, Kar Tong.,Wei, Yang Ye.,Ng, Chee Peng.,Colman, Alan.,...&许秀琴.(2012).RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility..
MLA	Poon, Kar Lai,et al."RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility".(2012).

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