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	Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer
	Yang, Donghai ; Fan, Xin ; Yin, Ping ; Wen, Qiang ; Yan, Feng ; Yuan, Sibo ; Liu, Bin ; Zhuang, Guohong ; Zhuang GH(庄国洪) ; Liu, Zhongchen
	2012-06-06
关键词	LIGAND AMPLIFICATION EXPRESSION CARCINOMA APOPTOSIS CELLS
英文摘要	Background: Decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor (TNFR) superfamily, is associated with anti-tumor immunity suppression. It is highly expressed in many tumors, and its expression can be regulated by the MAPK/MEK/ERK signaling pathway. The MAPK/MEK/ERK pathway has been reported to be a regulator in tumor occurrence, development and clonal expansion. External-signal regulated kinase (ERK) is a vital member of this pathway. Results: The expression of DcR3 and ERK1/2 in tumor tissues of gastric cancer patients was significantly higher than the non-cancerous group (P < 0.05). There was no statistical difference among tumor tissues from patients with different ages or gender, and even of different differentiation (P > 0.05). However, in patients with stage I gastric cancer, the DcR3 and ERK1/2 levels were significantly lower than patients with more advanced stages. Conclusions: DcR3 and ERK1/2 play a vital role in the development of gastric cancer, and they may be new markers for indicating the efficiency of gastric cancer treatment in the future.; 985 funds; Fujian Province nature science funds [2010D009]; Science and Technology Department of Fujian province provincial public research institutes for basic scientific research special [2011R10020-2]
语种	英语
出版者	BIOMED CENTRAL LTD
内容类型	期刊论文
源URL	[http://dx.doi.org/10.1186/1471-2172-13-28]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Yang, Donghai,Fan, Xin,Yin, Ping,et al. Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer[J],2012.
APA	Yang, Donghai.,Fan, Xin.,Yin, Ping.,Wen, Qiang.,Yan, Feng.,...&Liu, Zhongchen.(2012).Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer..
MLA	Yang, Donghai,et al."Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer".(2012).

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