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	Function of Helper T Cells in the Memory CTL-mediated Anti-tumor Immunity
	Gao FG(高丰光) ; Germain J.P.Fernendo(University of Queensland,Australia) ; 刘文军(University of Queensland,Australia)
	2004
关键词	Memory T cells Helper T cells Transgenic CD44
英文摘要	To investigate the role of CD4 + helper T (Th) cells in the memory CTL2mediated anti2tumor immunity , the RAG21 gene knock out mice were adoptively transferred with OT21 cells to generate the memory CTL , the C57BLP6 mice im2 munized with the epitope peptide of OVA specific Th cells and with different adjuvants were adoptively transferred with these memory2CTLs , and then the animals were challenged with tumor cells EG7. It was found that although the simple immuniza2 tion of mice with the epitope peptide of the OVA specific Th cells could generate more effect CTL , but this effect was not so strong enough to resist completely the challenges with tumor cells. Nevertheless , the memory CTL2mediated anti2tumor im2 mune effect required the helps of Th1 and Th2 cells. The cross2regulation between Th1 and Th2 cells seemed to be beneficial for the host to generate more effector CTL for mounting an efficient anti2tumor response. It concluded that the interaction be2 tween Th1 and Th2 cells might be more important than the single subset of Th cells in the memory CTL2mediated anti2tumor immune response. More attention should be paid in this regard for the future studies.
语种	英语
出版者	Chinese Journal of Microbiology and Immunology
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/8536]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Gao FG,Germain J.P.Fernendo,Liu WJ. Function of Helper T Cells in the Memory CTL-mediated Anti-tumor Immunity[J],2004.
APA	高丰光,Germain J.P.Fernendo,&刘文军.(2004).Function of Helper T Cells in the Memory CTL-mediated Anti-tumor Immunity..
MLA	高丰光,et al."Function of Helper T Cells in the Memory CTL-mediated Anti-tumor Immunity".(2004).

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