GA combined with structural comparison to improve the prediction of RNA secondary structure from comparative sequence alignment

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	GA combined with structural comparison to improve the prediction of RNA secondary structure from comparative sequence alignment
	Lin, Chen ; Tang, Zhenkun ; Jiang, Yi ; Yang, Chenhui ; Zou, Quan ; Lin C(林琛) ; Jiang Y(江弋) ; Yang CH(杨晨晖) ; Zou Q(邹权)
刊名	http://dx.doi.org/10.4156/jcit.vol6.issue11.45
	2011
关键词	Alignment Bioinformatics Forestry Genetic algorithms RNA
英文摘要	Comparative sequence analysis methods view multiple sequences as profiles for predicting RNA secondary structure. However, some structures may deviate from the real ones as mutation happens. During the computation of consensus structure, triples and pseudoknots also interfere. In this paper, to improve RNA secondary structure prediction, RNA secondary structure is represented as a forest. Structural similarity is measured by aligning two forests. Genetic algorithm is adopted to optimize free energy based fitness function. Experimental results demonstrate efficiency and effectiveness of the proposed framework.
语种	英语
出版者	Advanced Institute of Convergence Information Technology
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93041]
专题	信息技术－已发表论文
推荐引用方式 GB/T 7714	Lin, Chen,Tang, Zhenkun,Jiang, Yi,et al. GA combined with structural comparison to improve the prediction of RNA secondary structure from comparative sequence alignment[J]. http://dx.doi.org/10.4156/jcit.vol6.issue11.45,2011.
APA	Lin, Chen.,Tang, Zhenkun.,Jiang, Yi.,Yang, Chenhui.,Zou, Quan.,...&邹权.(2011).GA combined with structural comparison to improve the prediction of RNA secondary structure from comparative sequence alignment.http://dx.doi.org/10.4156/jcit.vol6.issue11.45.
MLA	Lin, Chen,et al."GA combined with structural comparison to improve the prediction of RNA secondary structure from comparative sequence alignment".http://dx.doi.org/10.4156/jcit.vol6.issue11.45 (2011).