Chemical exchange saturation transfer MRI using intermolecular double-quantum coherences with multiple refocusing pulses

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	Chemical exchange saturation transfer MRI using intermolecular double-quantum coherences with multiple refocusing pulses
	Lu, Jianhua ; Cai, Congbo ; Cai, Shuhui ; Chen, Zhong ; Zhou, Jinyuan ; Cai CB(蔡聪波) ; Cai SH(蔡淑惠) ; Chen Z(陈忠)
刊名	http://dx.doi.org/10.1016/j.mri.2014.03.001
	2014
关键词	DIPOLAR FIELD IN-VIVO HUMAN BRAIN 7 T INHOMOGENEOUS FIELDS SIGNAL ENHANCEMENT CONTRAST AGENTS TRANSFER CEST SOLUTION NMR RELAXATION
英文摘要	National Natural Science Foundation of China [11275161, U1232212]; National Institutes of Health [R01EB009731, R01CA166171]; Chemical exchange saturation transfer (CEST) provides a new type of image contrast in MRI. Due to the intrinsically low CEST effect, new and improved experimental techniques are required to achieve reliable and quantitative CEST images. In the present work, we proposed a novel and more sensitive CEST acquisition approach, based on the intermolecular double-quantum coherence with a module of multiple refocusing pulses (iDQC-MRP). Experiments were performed on creatine and egg white phantoms using a Varian 7 T animal MRI scanner. The iDQC-MRP CEST technique showed a substantial enhancement in CEST and nuclear Overhauser enhancement (NOE) signal intensities, compared to the standard single-quantum coherence approach. In addition, the iDQC-MRP approach increased the signal-to-noise ratio of acquired saturation images, compared to the conventional iDQC approach. The new iDQC-MRP CEST sequence provides a promising way for exploiting in vivo CEST and NOE imaging applications. (C) 2014 Elsevier Inc. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE INC
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/92675]
专题	信息技术－已发表论文
推荐引用方式 GB/T 7714	Lu, Jianhua,Cai, Congbo,Cai, Shuhui,et al. Chemical exchange saturation transfer MRI using intermolecular double-quantum coherences with multiple refocusing pulses[J]. http://dx.doi.org/10.1016/j.mri.2014.03.001,2014.
APA	Lu, Jianhua.,Cai, Congbo.,Cai, Shuhui.,Chen, Zhong.,Zhou, Jinyuan.,...&陈忠.(2014).Chemical exchange saturation transfer MRI using intermolecular double-quantum coherences with multiple refocusing pulses.http://dx.doi.org/10.1016/j.mri.2014.03.001.
MLA	Lu, Jianhua,et al."Chemical exchange saturation transfer MRI using intermolecular double-quantum coherences with multiple refocusing pulses".http://dx.doi.org/10.1016/j.mri.2014.03.001 (2014).