Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics

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	Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics
	Zhang, Linbao ; Liu, Xiaoli ; You, Liping ; Zhou, Di ; Yu, Junbao ; Zhao, Jianmin ; Feng, Jianghua ; Wu, Huifeng ; Feng JH(冯江华)
刊名	http://dx.doi.org/10.1002/clen.201100208
	2011-09
关键词	MUSSEL MYTILUS-EDULIS GLUCOSE DEGRADATION TIDAL FLATS EXPOSURE BIOCHEMISTRY BIOSORPTION GALLOPROVINCIALIS TRANSFORMATION SPECTROSCOPY METABONOMICS
英文摘要	Chinese Academy of Sciences, NSFC [41106102]; Technology Development Program Projects of Shandong Province [2008GG20005006, 2008GG3NS0700]; SDSFC [ZR2009CZ008]; CAS/SAFEA; Cadmium (Cd) has become an important heavy metal contaminant in the sediment and seawater along the Bohai Sea and been of great ecological risk due to its toxic effects to marine organisms. In this work, the toxicological effects caused by environmentally relevant concentrations (10 and 40 mu g L(-1)) of Cd were studied in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48, and 96 h. Both low (10 mu g L(-1)) and high (40 mu g L(-1)) doses of Cd caused the disturbances in energy metabolism and osmotic regulation and neurotoxicity based on the metabolic biomarkers such as succinate, alanine, branched chain amino acids, betaine, hypotaurine, and glutamate in clam gills after 24 h of exposure. However, the recovery of toxicological effects of Cd after exposure for 96 h was obviously observed in clam to Cd exposures. Overall, these results indicated that NMR-based metabolomics was applicable to elucidate the toxicological effects of heavy metal contaminants in the marine bioindicator.
语种	英语
出版者	CLEAN-SOIL AIR WATER
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/91632]
专题	物理技术－已发表论文
推荐引用方式 GB/T 7714	Zhang, Linbao,Liu, Xiaoli,You, Liping,et al. Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics[J]. http://dx.doi.org/10.1002/clen.201100208,2011.
APA	Zhang, Linbao.,Liu, Xiaoli.,You, Liping.,Zhou, Di.,Yu, Junbao.,...&冯江华.(2011).Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics.http://dx.doi.org/10.1002/clen.201100208.
MLA	Zhang, Linbao,et al."Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics".http://dx.doi.org/10.1002/clen.201100208 (2011).