High-Resolution MRS in the Presence of Field Inhomogeneity via Intermolecular Double-Quantum Coherences on a 3-T Whole-Body Scanner

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	High-Resolution MRS in the Presence of Field Inhomogeneity via Intermolecular Double-Quantum Coherences on a 3-T Whole-Body Scanner
	Lin, Y. Q. ; Gu, T. L. ; Chen, Z. ; Kennedy, S. ; Jacob, M. ; Zhong, J. H. ; Chen Z(陈忠)
刊名	http://dx.doi.org/10.1002/mrm.22224
	2010-02
关键词	NUCLEAR-MAGNETIC-RESONANCE MULTIPLE SPIN ECHOES IN-VIVO DETECTION NMR-SPECTRA HUMAN BRAIN SOLVENT SUPPRESSION SPECTROSCOPY FILTER GLUTATHIONE HEAD
英文摘要	National Institutes of Health [NS41048]; NNSF of China [10774125]; Signals from intermolecular double-quantum coherence (iDQCs) have been shown to be insensitive to macroscopic field inhomogeneities and thus enable acquisition of high resolution MR spectroscopy in the presence of large inhomo geneous fields. In this paper, localized iDQC (1)H spectroscopy on a whole-body 3-T MR scanner is reported. Experiments with a brain metabolite phantom were performed to quantify characteristics of the iDQC signal under different conditions. The feasibility of in vivo iDQC high-resolution MR spectroscopy in the presence of large intrinsic and external field inhomogeneity (in the order of hundreds of hertz) was demonstrated in the whole cerebellum of normal volunteers in a scan time of about 6.5 min. Major metabolite peaks were well resolved in the reconstructed one-dimensional spectra projected from two-dimensional iDQC acquisitions. Investigations on metabolite ratios signal-to-noise ratio, and line width were performed and compared with results obtained with conventional point-resolved spectroscopy/MR spectroscopy in homogeneous fields Metabolite ratios from iDQC results showed excellent consistency under different in vitro and in vivo conditions, and they were similar to those from point-resolved spectroscopy with small voxel sizes in homogeneous fields. MR spectroscopy with iDQCs can be applied potentially for quantification of gross metabolite changes due to diseases in large brain volumes with high field inhomogeneity. Magn Reson Med 63:303-311, 2010. (C) 2010 Wiley-Liss, Inc.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/70105]
专题	物理技术－已发表论文
推荐引用方式 GB/T 7714	Lin, Y. Q.,Gu, T. L.,Chen, Z.,et al. High-Resolution MRS in the Presence of Field Inhomogeneity via Intermolecular Double-Quantum Coherences on a 3-T Whole-Body Scanner[J]. http://dx.doi.org/10.1002/mrm.22224,2010.
APA	Lin, Y. Q..,Gu, T. L..,Chen, Z..,Kennedy, S..,Jacob, M..,...&陈忠.(2010).High-Resolution MRS in the Presence of Field Inhomogeneity via Intermolecular Double-Quantum Coherences on a 3-T Whole-Body Scanner.http://dx.doi.org/10.1002/mrm.22224.
MLA	Lin, Y. Q.,et al."High-Resolution MRS in the Presence of Field Inhomogeneity via Intermolecular Double-Quantum Coherences on a 3-T Whole-Body Scanner".http://dx.doi.org/10.1002/mrm.22224 (2010).