Fast acquisition of high-resolution NMR spectra in inhomogeneous fields via intermolecular double-quantum coherences

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	Fast acquisition of high-resolution NMR spectra in inhomogeneous fields via intermolecular double-quantum coherences
	Chen, Z. ; Cai, S. H. ; Chen, Z. W. ; Zhong, J. H. ; Chen Z(陈忠)
刊名	http://dx.doi.org/10.1063/1.3076046
	2009-02-28
关键词	NUCLEAR-MAGNETIC-RESONANCE SINGLE-SIDED SENSOR EX-SITU NMR IN-VIVO SOLVENT SUPPRESSION CRAZED EXPERIMENT DIPOLAR FIELD SPECTROSCOPY DYNAMICS LIQUIDS
英文摘要	NNSF of China [10774125, 10875101]; Higher Education of China [200803840019]; NCET; MOE of China; NIH [NS41048.]; A pulse sequence, IDEAL-II, is proposed based on the concept of intermolecular dipolar-interaction enhanced all lines [Z. Chen , J. Am. Chem. Soc. 126, 446 (2004)] for obtaining one-dimensional (1D) high-resolution liquid NMR spectra in inhomogeneous fields via two-dimensional acquisitions. With the new acquisition scheme, the range of magnetic field inhomogeneity rather than chemical shift is sampled in the indirect dimension. This enables a great reduction in acquisition time and amount of data, much improved over the original IDEAL implementation. It is applicable to both isolated and J-coupled spin systems in liquid. For the latter, apparent J coupling constants are magnified threefold in spectra obtained with this sequence. This allows a more accurate measurement of J coupling constants in the cases of small J coupling constants or large inhomogeneous fields. Analytical expression was derived based on intermolecular multiple-quantum coherence treatments. Solution samples that were purposely deshimmed and biological samples with intrinsic field inhomogeneities were tested. Experimental results demonstrate that this sequence retains useful structural information including chemical shifts, relative peak areas, and multiplet patterns of J coupling even when the field inhomogeneity is severe enough to almost erase all spectroscopic information with conventional 1D single-quantum coherence techniques. This sequence is more applicable to weakly coupled and uncoupled spin systems, potentially useful for studying metabolites in in vivo NMR spectroscopy and for characterizing technologically important new materials in combinatorial chemistry.
语种	英语
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/70098]
专题	物理技术－已发表论文
推荐引用方式 GB/T 7714	Chen, Z.,Cai, S. H.,Chen, Z. W.,et al. Fast acquisition of high-resolution NMR spectra in inhomogeneous fields via intermolecular double-quantum coherences[J]. http://dx.doi.org/10.1063/1.3076046,2009.
APA	Chen, Z.,Cai, S. H.,Chen, Z. W.,Zhong, J. H.,&陈忠.(2009).Fast acquisition of high-resolution NMR spectra in inhomogeneous fields via intermolecular double-quantum coherences.http://dx.doi.org/10.1063/1.3076046.
MLA	Chen, Z.,et al."Fast acquisition of high-resolution NMR spectra in inhomogeneous fields via intermolecular double-quantum coherences".http://dx.doi.org/10.1063/1.3076046 (2009).